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AB140899

Anti-NR2E3/RNR antibody

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(1 Publication)

Rabbit Polyclonal NR2E3/RNR antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NR2E3.

View Alternative Names

PNR, RNR, NR2E3, Photoreceptor-specific nuclear receptor, Nuclear receptor subfamily 2 group E member 3, Retina-specific nuclear receptor

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NR2E3/RNR antibody (AB140899)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NR2E3/RNR antibody (AB140899)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human retina tissue labelling NR2E3/RNR with ab140899 at 7 μg/ml (after heat-induced antigen retrieval).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human NR2E3. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5X4

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "7 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle|Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NR2E3/RNR protein also known as nuclear receptor subfamily 2 group E member 3 plays an important role in gene regulation particularly in retinal cells. Its molecular weight is approximately 45 kDa. This nuclear receptor expresses in specific tissues especially within the retina where it influences photoreceptor health and development. Its expression primarily affects rods and cones impacting the overall visual function.
Biological function summary

NR2E3/RNR functions as a transcription factor fine-tuning the expression of genes vital for photoreceptor cells. It forms part of a complex with other transcription factors including NRL and CRX which coordinate to regulate cell differentiation and response to light. This protein significantly influences the switch between rod and cone photoreceptor cell fates impacting the balance and functionality of these critical cells in the retina.

Pathways

NR2E3/RNR participates in the phototransduction and visual cycle pathways. These pathways account for the conversion of light signals into neural signals facilitating vision. In the phototransduction pathway NR2E3/RNR is related to proteins such as rhodopsin and transducin playing a role in modulating photoreceptor roles. Through these pathways it contributes to maintaining retinal integrity and proper light response.

Mutations in NR2E3 correlate with certain retinal degenerative diseases such as Enhanced S-Cone Syndrome (ESCS) and retinitis pigmentosa. These diseases often link to its interactions with proteins like CRX which also play roles in retinal health. Disruptions in NR2E3/RNR function can lead to photoreceptor cell dysfunction and degeneration highlighting its importance in retinal disease mechanisms and offering potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
See full target information NR2E3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in genetics 12:670746 PubMed34306014

2021

Is a Potential Biomarker of Tumor Microenvironment Immunomodulation and Favorable Prognosis in Patients With Head and Neck Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Qingxiang Li,Le Xu,Yuke Li,Rong Yang,Qiao Qiao,Yifei Wang,Lin Wang,Yuxing Guo,Chuanbin Guo
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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