Rabbit Polyclonal NR2E3/RNR antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human NR2E3.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human NR2E3. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y5X4
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Common marmoset | Predicted |
| Gorilla | Predicted |
| Hamster | Predicted |
| Monkey | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 7 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Hamster, Monkey, Gorilla, Common marmoset | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
Alternative names
PNR, RNR, NR2E3, Photoreceptor-specific nuclear receptor, Nuclear receptor subfamily 2 group E member 3, Retina-specific nuclear receptor
Recommended products
Rabbit Polyclonal NR2E3/RNR antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human NR2E3.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human NR2E3. The exact immunogen used to generate this antibody is proprietary information. Database link Q9Y5X4
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle, Stable for 12 months at -20°C
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The NR2E3/RNR protein also known as nuclear receptor subfamily 2 group E member 3 plays an important role in gene regulation particularly in retinal cells. Its molecular weight is approximately 45 kDa. This nuclear receptor expresses in specific tissues especially within the retina where it influences photoreceptor health and development. Its expression primarily affects rods and cones impacting the overall visual function.
- Biological function summary
NR2E3/RNR functions as a transcription factor fine-tuning the expression of genes vital for photoreceptor cells. It forms part of a complex with other transcription factors including NRL and CRX which coordinate to regulate cell differentiation and response to light. This protein significantly influences the switch between rod and cone photoreceptor cell fates impacting the balance and functionality of these critical cells in the retina.
- Pathways
NR2E3/RNR participates in the phototransduction and visual cycle pathways. These pathways account for the conversion of light signals into neural signals facilitating vision. In the phototransduction pathway NR2E3/RNR is related to proteins such as rhodopsin and transducin playing a role in modulating photoreceptor roles. Through these pathways it contributes to maintaining retinal integrity and proper light response.
- Associated diseases and disorders
Mutations in NR2E3 correlate with certain retinal degenerative diseases such as Enhanced S-Cone Syndrome (ESCS) and retinitis pigmentosa. These diseases often link to its interactions with proteins like CRX which also play roles in retinal health. Disruptions in NR2E3/RNR function can lead to photoreceptor cell dysfunction and degeneration highlighting its importance in retinal disease mechanisms and offering potential therapeutic targets.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NR2E3/RNR antibody (ab140899)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human retina tissue labelling NR2E3/RNR with ab140899 at 7 μg/ml (after heat-induced antigen retrieval).
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Product protocols
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