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AB172542

Anti-NR2E3/RNR antibody

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(2 Publications)

Mouse Polyclonal NR2E3/RNR antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NR2E3.

View Alternative Names

PNR, RNR, NR2E3, Photoreceptor-specific nuclear receptor, Nuclear receptor subfamily 2 group E member 3, Retina-specific nuclear receptor

1 Images
Western blot - Anti-NR2E3/RNR antibody (AB172542)
  • WB

Supplier Data

Western blot - Anti-NR2E3/RNR antibody (AB172542)

All lanes:

Western blot - Anti-NR2E3/RNR antibody (ab172542) at 1 µg/mL

Lane 1:

NR2E3/RNR transfected 293T cell lysate at 15 µL

Lane 2:

Non transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 45 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NR2E3.

Q9Y5X4

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NR2E3/RNR protein also known as nuclear receptor subfamily 2 group E member 3 plays an important role in gene regulation particularly in retinal cells. Its molecular weight is approximately 45 kDa. This nuclear receptor expresses in specific tissues especially within the retina where it influences photoreceptor health and development. Its expression primarily affects rods and cones impacting the overall visual function.
Biological function summary

NR2E3/RNR functions as a transcription factor fine-tuning the expression of genes vital for photoreceptor cells. It forms part of a complex with other transcription factors including NRL and CRX which coordinate to regulate cell differentiation and response to light. This protein significantly influences the switch between rod and cone photoreceptor cell fates impacting the balance and functionality of these critical cells in the retina.

Pathways

NR2E3/RNR participates in the phototransduction and visual cycle pathways. These pathways account for the conversion of light signals into neural signals facilitating vision. In the phototransduction pathway NR2E3/RNR is related to proteins such as rhodopsin and transducin playing a role in modulating photoreceptor roles. Through these pathways it contributes to maintaining retinal integrity and proper light response.

Mutations in NR2E3 correlate with certain retinal degenerative diseases such as Enhanced S-Cone Syndrome (ESCS) and retinitis pigmentosa. These diseases often link to its interactions with proteins like CRX which also play roles in retinal health. Disruptions in NR2E3/RNR function can lead to photoreceptor cell dysfunction and degeneration highlighting its importance in retinal disease mechanisms and offering potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
See full target information NR2E3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular life sciences : CMLS 78:6505-6532 PubMed34420069

2021

A look into retinal organoids: methods, analytical techniques, and applications.

Applications

Unspecified application

Species

Unspecified reactive species

Tess A V Afanasyeva,Julio C Corral-Serrano,Alejandro Garanto,Ronald Roepman,Michael E Cheetham,Rob W J Collin

Scientific reports 7:10662 PubMed28878246

2017

Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Tilak Khanal,Kwangmin Choi,Yuet-Kin Leung,Jiang Wang,Dasom Kim,Vinothini Janakiram,Sung-Gook Cho,Alvaro Puga,Shuk-Mei Ho,Kyounghyun Kim
View all publications
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