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AB191139

Anti-NRG1 antibody - C-terminal

5

(2 Reviews)

|

(10 Publications)

Rabbit Polyclonal NRG1 antibody. C-terminal. Suitable for IHC-P, ICC, WB, IHC-Fr and reacts with Rat, Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human NRG1 aa 600 to C-terminus.

View Alternative Names

GGF, HGL, HRGA, NDF, SMDF, NRG1, Pro-NRG1

5 Images
Immunocytochemistry - Anti-NRG1 antibody - C-terminal (AB191139)
  • ICC

Supplier Data

Immunocytochemistry - Anti-NRG1 antibody - C-terminal (AB191139)

Immunocytochemical analysis of HeLa cells labeling NRG1 with ab191139 at 1 μg/ml.

Immunohistochemistry (Frozen sections) - Anti-NRG1 antibody - C-terminal (AB191139)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-NRG1 antibody - C-terminal (AB191139)

Immunohistochemical analysis of frozen Rat Intestine Tissue labeling NRG1 with ab191139 at 1 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRG1 antibody - C-terminal (AB191139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRG1 antibody - C-terminal (AB191139)

Immunohistochemical analysis of paraffin-embedded Rat Intestine Tissue labeling NRG1 with ab191139 at 1 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRG1 antibody - C-terminal (AB191139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRG1 antibody - C-terminal (AB191139)

Immunohistochemical analysis of paraffin-embedded Rat Intestine Cancer Tissue labeling NRG1 with ab191139 at 1 μg/ml.

Western blot - Anti-NRG1 antibody - C-terminal (AB191139)
  • WB

Supplier Data

Western blot - Anti-NRG1 antibody - C-terminal (AB191139)

All lanes:

Western blot - Anti-NRG1 antibody - C-terminal (ab191139) at 0.5 µg/mL

Lane 1:

Rat Spleen Tissue Lysate

Lane 2:

Rat Kidney Tissue Lysate

Lane 3:

Rat Brain Tissue Lysate

Lane 4:

HeLa Cell Lysate

Lane 5:

SMMC Cell Lysate

Predicted band size: 70 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

ICC, WB, IHC-P, IHC-Fr

applications

Immunogen

Synthetic Peptide within Human NRG1 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q02297

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "0.5-1 µg/mL", "ICC-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICC-species-checked": "predicted", "ICC-species-dilution-info": "", "ICC-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "0.5-1 µg/mL", "IHCFr-species-notes": "<p></p>" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICC-species-checked": "predicted", "ICC-species-dilution-info": "", "ICC-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuregulin 1 (NRG1) also known as heregulin beta 1 is a member of the neuregulin protein family. It is a signaling protein with a molecular mass that typically ranges around 44 kDa. Researchers have found NRG1 expressed in various tissues including the heart brain and certain epithelial cells. It plays important roles in cell-cell communication by binding to ErbB family receptors particularly ErbB3 and ErbB4 which trigger downstream signaling processes.
Biological function summary

NRG1 is involved in several cellular activities such as cell growth survival and differentiation. It is not part of a complex but acts directly through its interactions with receptor tyrosine kinases in the ErbB receptor family. NRG1 influences cardiac development and neural function by mediating these cellular processes promoting the development and maintenance of neural and cardiac tissues.

Pathways

NRG1 is involved in the PI3K-Akt and MAPK/ERK signaling pathways. These pathways are critical for cellular growth differentiation and survival supporting the functions of NRG1 in various tissues. The interaction with ErbB2 and ErbB3 receptors is especially significant for these pathways as they help regulate the cellular responses initiated by NRG1 signaling.

NRG1 plays an impactful role in the development of certain types of cancer and schizophrenia. Dysregulation or mutations in the NRG1 gene can lead to altered signaling pathways which are connected to the pathogenesis of these conditions. In cancer the interaction with ErbB2 has been under investigation as it may promote tumorigenesis. In the context of schizophrenia NRG1's effects on neural development and neurotransmission are linked with the disorder's symptoms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed : 10867024, PubMed : 7902537). Binds to ERBB3 (PubMed : 20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV : ITGB3 or ITGA6 : ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed : 20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).
See full target information NRG1
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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 55: PubMed39950316

2025

Elevated neuregulin‑1 expression modulates tumor malignancy and autophagy in esophageal squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yen-Chiang Tseng,Pei-Feng Liu,Yu-Ru Chen,Wen-Hsin Yang,Chia-Che Chang,Hsueh-Wei Chang,Cheng-Hsin Lee,Yih-Gang Goan,Chih-Wen Shu

BMC genomics 25:814 PubMed39210279

2024

Discovery of NRG1-VII: the myeloid-derived class of NRG1.

Applications

Unspecified application

Species

Unspecified reactive species

Miguel A Berrocal-Rubio,Yair David Joseph Pawer,Marija Dinevska,Ricardo De Paoli-Iseppi,Samuel S Widodo,Josie Gleeson,Nadia Rajab,Will De Nardo,Jeannette Hallab,Anran Li,Theo Mantamadiotis,Michael B Clark,Christine A Wells

Experimental and therapeutic medicine 26:468 PubMed37664684

2023

Effect of thymosin β4 on lipopolysaccharide‑stimulated brain microvascular endothelial cell remodeling: A possible role in blood‑brain barrier injury.

Applications

Unspecified application

Species

Unspecified reactive species

William Stewart,Christina Hejl,Rakeshwar S Guleria,Sudhiranjan Gupta

Disease models & mechanisms 16: PubMed36912192

2023

Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth.

Applications

Unspecified application

Species

Unspecified reactive species

Toni T Lemmetyinen,Emma W Viitala,Linnea Wartiovaara,Tuomas Kaprio,Jaana Hagström,Caj Haglund,Pekka Katajisto,Timothy C Wang,Eva Domènech-Moreno,Saara Ollila

Nature communications 14:1559 PubMed36944680

2023

Cellular mechanisms of heterogeneity in NF2-mutant schwannoma.

Applications

Unspecified application

Species

Unspecified reactive species

Christine Chiasson-MacKenzie,Jeremie Vitte,Ching-Hui Liu,Emily A Wright,Elizabeth A Flynn,Shannon L Stott,Marco Giovannini,Andrea I McClatchey

Science advances 9:eadd8977 PubMed36706185

2023

Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Liu,Min Zhang,Xinlong Yan,Yanli Ni,Yandong Gong,Cong Wang,Xiaoling Zhang,Lingfei Wan,Hui Yang,Chen Ge,Yunqiao Li,Wenxue Zou,Rui Huang,Xiaohui Li,Bing Sun,Bing Liu,Jinbo Yue,Jinming Yu

Cancer cell 41:252-271.e9 PubMed36525970

2022

Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Anxo Martinez-Ordoñez,Angeles Duran,Marc Ruiz-Martinez,Tania Cid-Diaz,Xiao Zhang,Qixiu Han,Hiroto Kinoshita,Yu Muta,Juan F Linares,Hiroaki Kasashima,Yuki Nakanishi,Mohamed Omar,Sadaaki Nishimura,Leandro Avila,Masakazu Yashiro,Kiyoshi Maeda,Tania Pannellini,Alessio Pigazzi,Giorgio Inghirami,Luigi Marchionni,Darren Sigal,Maria T Diaz-Meco,Jorge Moscat

Journal of integrative neuroscience 20:613-622 PubMed34645094

2021

Prenatal sevoflurane exposure causes abnormal development of the entorhinal cortex in rat offspring.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Gao,Tianyun Zhao,Yanxin Chen,Zhixiang Sun,Junming Lu,Ziwen Shi,Xingrong Song

Cell stem cell 27:646-662.e7 PubMed32693086

2020

Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Thierry Jardé,Wing Hei Chan,Fernando J Rossello,Tanvir Kaur Kahlon,Mandy Theocharous,Teni Kurian Arackal,Tracey Flores,Mégane Giraud,Elizabeth Richards,Eva Chan,Genevieve Kerr,Rebekah M Engel,Mirsada Prasko,Jacqueline F Donoghue,Shin-Ichi Abe,Toby J Phesse,Christian M Nefzger,Paul J McMurrick,David R Powell,Roger J Daly,Jose M Polo,Helen E Abud

PloS one 14:e0216527 PubMed31107888

2019

The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin.

Applications

Unspecified application

Species

Unspecified reactive species

Frank L Rice,George Houk,James P Wymer,Sara J C Gosline,Justin Guinney,Jianqiang Wu,Nancy Ratner,Michael P Jankowski,Salvo La Rosa,Marilyn Dockum,James R Storey,Steven L Carroll,Phillip J Albrecht,Vincent M Riccardi
View all publications
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