JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB77597

Anti-NRG3 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Goat Polyclonal NRG3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NRG3 aa 650-700.

View Alternative Names

Pro-NRG3, NRG3

1 Images
Western blot - Anti-NRG3 antibody (AB77597)
  • WB

Unknown

Western blot - Anti-NRG3 antibody (AB77597)

Note : The additional 37 kDa band of unknown identity was consistently observed and was successfully blocked by incubation with the immunizing peptide.

All lanes:

Western blot - Anti-NRG3 antibody (ab77597) at 0.3 µg/mL

All lanes:

human brain (cerebellum) lysate in RIPA buffer at 35 µg

Predicted band size: 77 kDa

Observed band size: 37 kDa,75 kDa

false

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human NRG3 aa 650-700. The exact immunogen used to generate this antibody is proprietary information.

P56975

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NRG3 also known as Neuregulin-3 is a protein with a molecular mass around 71 kDa. It is a member of the neuregulin family which includes proteins that play roles in cell communication and development. NRG3 is expressed in the central nervous system with notable expression in brain regions like the cerebral cortex and hippocampus. It acts mechanically as a signaling molecule binding to ErbB4 a receptor tyrosine kinase to initiate downstream signaling cascades.
Biological function summary

NRG3 influences neural development and synaptic plasticity contributing to the formation and maturation of neuronal circuits. It is part of the epidermal growth factor (EGF)-like family which is involved in cell-to-cell communication necessary for various aspects of development. This protein interacts with ErbB4 to form a receptor-ligand complex essential for signal transduction. These interactions play important roles in brain development and maintenance of normal neural functions.

Pathways

NRG3 plays a role in pathways like the ErbB signaling and the PI3K/AKT pathways. It engages in interactions majorly with ErbB4 facilitating neuronal signaling processes essential for brain function. In the PI3K/AKT pathway NRG3-ErbB4 interaction supports cell survival and growth linking it with other signaling proteins such as PI3K and AKT. This positions NRG3 as an important player in maintaining cellular responses and neuronal homeostasis.

NRG3 has connections with schizophrenia and autism spectrum disorders. Alterations in NRG3 signaling have been associated with the pathophysiology of schizophrenia where abnormal ErbB4-NRG3 interactions contribute to neural development issues leading to the disease. Changes in the signaling pathway involving NRG3 and ErbB4 also relate to autism spectrum disorders indicating its role in neural developmental disorders. Understanding NRG3's function and interactions could provide insights into therapeutic targets for these conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
See full target information NRG3
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:e2101329 PubMed34643063

2021

The m A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Yu,Yuanchu She,Lixin Yang,Mengru Zhuang,Peng Han,Jianhui Liu,Xiaoyan Lin,Nijia Wang,Mengxian Chen,Chunxuan Jiang,Yujia Zhang,Yujing Yuan,Sheng-Jian Ji

Cerebral cortex (New York, N.Y. : 1991) 30:3325-3339 PubMed31897479

2020

Temporal Dynamics of the Neuregulin-ErbB Network in the Murine Prefrontal Cortex across the Lifespan.

Applications

Unspecified application

Species

Unspecified reactive species

Clare Paterson,Brooke Cumming,Amanda J Law
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB109256

Anti-NRG3 antibody [EPR4148]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-NRG3 antibody [EPR4148] (AB109256)

  • 3
  • 1
Primary Antibodies

AB232014

Anti-NRG3 antibody [EPR4148] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-NRG3 antibody [EPR4148] - BSA and Azide free (AB232014)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB281228

Anti-NRG1 antibody [EPR23075-57] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-NRG1 antibody [EPR23075-57] - BSA and Azide free (Capture) (AB281228)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB126729

Anti-Netrin 1 antibody [EPR5428]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunoprecipitation - Anti-Netrin 1 antibody [EPR5428] (AB126729)

  • 4
  • 3
Proteins & Peptides

AB259410

Recombinant human TNF alpha protein (Active)

Premium Bioactive

Flow Cytometry - Recombinant human TNF alpha protein (Active) (AB259410)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com