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AB239580

Anti-NRG4 antibody [C2]

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(3 Publications)

Mouse Monoclonal NRG4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Pro-neuregulin-4, membrane-bound isoform aa 1-100.

View Alternative Names

Pro-NRG4, NRG4

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRG4 antibody [C2] (AB239580)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRG4 antibody [C2] (AB239580)

Paraffin-embedded human brain tissue stained for NRG4 using ab239580 at 20 μg/mL in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRG4 antibody [C2] (AB239580)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRG4 antibody [C2] (AB239580)

Paraffin-embedded human lung cancer tissue stained for NRG4 using ab239580 at 20 μg/mL in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRG4 antibody [C2] (AB239580)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRG4 antibody [C2] (AB239580)

Paraffin-embedded human stomach tissue stained for NRG4 using ab239580 at 20 μg/mL in immunohistochemical analysis.

Western blot - Anti-NRG4 antibody [C2] (AB239580)
  • WB

Supplier Data

Western blot - Anti-NRG4 antibody [C2] (AB239580)

All lanes:

Western blot - Anti-NRG4 antibody [C2] (ab239580) at 2 µg/mL

All lanes:

Recombinant human NRG4 protein

Predicted band size: 13 kDa

false

Western blot - Anti-NRG4 antibody [C2] (AB239580)
  • WB

Supplier Data

Western blot - Anti-NRG4 antibody [C2] (AB239580)

All lanes:

Western blot - Anti-NRG4 antibody [C2] (ab239580) at 5 µg/mL

All lanes:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Secondary

All lanes:

HRP-Goat Anti-Mouse IgG at 0.2 µg/mL

Predicted band size: 13 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C2

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Pro-neuregulin-4, membrane-bound isoform aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q8WWG1

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Complementary Products

Proteins & Peptides

AB174432

Recombinant Human NRG4 protein

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Proteins & Peptides

AB276735

Recombinant Human NRG2 protein (His tag)

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Proteins & Peptides

AB282401

Recombinant human NRG1 protein (Active)

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Primary Antibodies

AB75813

Anti-NCAM1 antibody [EP2567Y]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [EP2567Y] (AB75813)

  • 4
  • 7
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from TCS.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neuregulin 4 (NRG4) is a member of the neuregulin family. It functions as a signaling molecule with a role in cell communication. NRG4 weighs approximately 40 kDa and mainly expresses in adipose tissue and the brain. It binds to erythroblastic leukemia viral oncogene homolog (ErbB) family receptors especially ErbB4 to execute its functions. These bindings initiate a cascade of intracellular events impacting various cellular activities.
Biological function summary

The protein NRG4 plays a significant role in regulating energy metabolism and maintaining homeostasis. It is not part of a complex but as a ligand it interacts directly with its receptor ErbB4. NRG4 activity helps regulate liver lipid metabolism preventing excessive lipid accumulation. Furthermore NRG4 involvement extends to pancreatic function where it aids in preserving insulin sensitivity with implications for glucose homeostasis.

Pathways

The protein NRG4 acts within the ErbB signaling pathway which is critical for cellular growth and differentiation. In this pathway NRG4 enhances the proliferation and differentiation of cells by activating the ErbB4 receptor. NRG4 also interfaces with the PI3K/AKT pathway playing a role in metabolic processes and cellular survival. The interaction with ErbB4 signifies its relation to other neuregulin proteins like NRG1 which also engage this receptor family showcasing their coordinated impact on metabolic regulation.

The protein NRG4 has links to metabolic disorders such as obesity and type 2 diabetes. Lower levels of NRG4 correlate with increased risk of these conditions highlighting its importance in metabolic health. NRG4 also interacts with inflammatory cytokines in the context of obesity where an imbalance can exacerbate metabolic dysregulation. Additionally in type 2 diabetes the target's association with insulin sensitivity indicates a therapeutic potential alongside its interactive partner ErbB4.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
See full target information Pro-neuregulin-4, membrane-bound isoform
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic surgery and research 20:835 PubMed40999516

2025

Neuregulin 4 inhibits synovial macrophage pro-inflammatory polarization via ErbB4/Stat5b/NF-κB signaling to alleviate osteoarthritis progression.

Applications

Unspecified application

Species

Unspecified reactive species

Daoliang Jiang,Xiaoli Xu,Wenjing Yang,Mengjia Tang,Yuping Zhang,Lingfeng Shi,Jiongyu Hu

Frontiers in physiology 12:783341 PubMed35035359

2021

Exercise Alleviates the Apolipoprotein A5-Toll-Like Receptor 4 Axis Impairment in Mice With High-Fat Diet-Induced Non-alcoholic Steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Yu,Lina Yu,Nuo Cheng,Xiaoguang Liu,Chunlu Fang,Shujing Liu,Lin Zhu

eNeuro 8: PubMed33495243

2021

Neuregulin-4 Is Required for Maintaining Soma Size of Pyramidal Neurons in the Motor Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Blanca Paramo,Sven O Bachmann,Stéphane J Baudouin,Isabel Martinez-Garay,Alun M Davies
View all publications
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Product promise

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