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AB154675

Anti-NRIP antibody

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(1 Publication)

Rabbit Polyclonal NRIP antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DCAF6 aa 350-700.

View Alternative Names

IQWD1, MSTP055, DCAF6, DDB1- and CUL4-associated factor 6, Androgen receptor complex-associated protein, IQ motif and WD repeat-containing protein 1, Nuclear receptor interaction protein, ARCAP, NRIP

1 Images
Western blot - Anti-NRIP antibody (AB154675)
  • WB

Unknown

Western blot - Anti-NRIP antibody (AB154675)

7.5% SDS PAGE

All lanes:

Western blot - Anti-NRIP antibody (ab154675) at 1/1000 dilution

Lane 1:

HeLa S3 whole cell lysate at 30 µg

Lane 2:

HepG2 whole cell lysate at 30 µg

Predicted band size: 96 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human DCAF6 aa 350-700. The exact immunogen used to generate this antibody is proprietary information.

Q58WW2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Nuclear Receptor Interacting Protein (NRIP) also known as NRIP1 or RIP140 is an essential coregulator in gene expression. It weighs about 115 kDa and interacts with various nuclear receptors. Scientists find NRIP expression in several tissues including the heart skeletal muscle and adipose tissue indicating its broad influence on biological function. Its mechanical role involves modulation of transcriptional activities by interacting with other proteins and DNA.
Biological function summary

NRIP influences energy homeostasis and reproductive processes. It forms part of transcriptional complexes with nuclear receptors aiding in regulating genes involved in lipid metabolism and glucose homeostasis. NRIP's involvement extends to the reproductive system where it affects the expression of genes required for fertility. The protein's role in these processes marks its importance in the regulation of fundamental biological functions.

Pathways

NRIP plays a role in lipid metabolism and energy balance pathways. It interacts within the peroxisome proliferator-activated receptor (PPAR) and estrogen receptor pathways influencing cellular energy status and fat storage. Proteins like PPARα and PPARγ show close relations with NRIP in these pathways where NRIP acts as a coregulator to fine-tune gene expression that controls fatty acid oxidation and adipogenesis.

NRIP's disruption links to metabolic syndromes and infertility. Misregulation of NRIP influences conditions like obesity and type 2 diabetes highlighting its role in energy balance. Additionally NRIP's connection with estrogen receptors ties it to reproductive disorders where altered expression patterns can lead to fertility issues. Understanding NRIP interactions with proteins like estrogen receptors can provide insights into therapeutic targets for related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
See full target information DCAF6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of translational research 14:8117-8128 PubMed36505312

2022

miR-370 impacts the biological behavior of lung cancer cells by targeting the SMAD1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaohui Tang,Yongjun Jiang,Sijuan Ding,Shaohui Jiang,Ruoting Tang,Pengfei Luo
View all publications
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