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Rabbit Polyclonal NRIP antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human DCAF6 aa 350-700.

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Images

Western blot - Anti-NRIP antibody (AB154675), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human DCAF6 aa 350-700. The exact immunogen used to generate this antibody is proprietary information. Database link Q58WW2

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested

Tested
Tested

Species
Human
Dilution info
1/500.00000 - 1/3000.00000
Notes

-

Target data

Function

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Alternative names

IQWD1, MSTP055, DCAF6, DDB1- and CUL4-associated factor 6, Androgen receptor complex-associated protein, IQ motif and WD repeat-containing protein 1, Nuclear receptor interaction protein, ARCAP, NRIP

Recommended products

Rabbit Polyclonal NRIP antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human DCAF6 aa 350-700.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Recombinant Fragment Protein within Human DCAF6 aa 350-700. The exact immunogen used to generate this antibody is proprietary information. Database link Q58WW2
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The Nuclear Receptor Interacting Protein (NRIP) also known as NRIP1 or RIP140 is an essential coregulator in gene expression. It weighs about 115 kDa and interacts with various nuclear receptors. Scientists find NRIP expression in several tissues including the heart skeletal muscle and adipose tissue indicating its broad influence on biological function. Its mechanical role involves modulation of transcriptional activities by interacting with other proteins and DNA.

Biological function summary

NRIP influences energy homeostasis and reproductive processes. It forms part of transcriptional complexes with nuclear receptors aiding in regulating genes involved in lipid metabolism and glucose homeostasis. NRIP's involvement extends to the reproductive system where it affects the expression of genes required for fertility. The protein's role in these processes marks its importance in the regulation of fundamental biological functions.

Pathways

NRIP plays a role in lipid metabolism and energy balance pathways. It interacts within the peroxisome proliferator-activated receptor (PPAR) and estrogen receptor pathways influencing cellular energy status and fat storage. Proteins like PPARα and PPARγ show close relations with NRIP in these pathways where NRIP acts as a coregulator to fine-tune gene expression that controls fatty acid oxidation and adipogenesis.

Associated diseases and disorders

NRIP's disruption links to metabolic syndromes and infertility. Misregulation of NRIP influences conditions like obesity and type 2 diabetes highlighting its role in energy balance. Additionally NRIP's connection with estrogen receptors ties it to reproductive disorders where altered expression patterns can lead to fertility issues. Understanding NRIP interactions with proteins like estrogen receptors can provide insights into therapeutic targets for related diseases.

Product promise

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1 product image

  • Western blot - Anti-NRIP antibody (ab154675), expandable thumbnail

    Western blot - Anti-NRIP antibody (ab154675)

    7.5% SDS PAGE

    All lanes: Western blot - Anti-NRIP antibody (ab154675) at 1/1000 dilution

    Lane 1: HeLa S3 whole cell lysate at 30 µg

    Lane 2: HepG2 whole cell lysate at 30 µg

    Predicted band size: 96 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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