Rabbit Polyclonal NRK antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human NRK aa 800-1000.
Images
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human NRK aa 800-1000. The exact immunogen used to generate this antibody is proprietary information. Database link Q7Z2Y5
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/200.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target data
Function
May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity).
Alternative names
Nik-related protein kinase, NRK
Recommended products
Rabbit Polyclonal NRK antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human NRK aa 800-1000.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human NRK aa 800-1000. The exact immunogen used to generate this antibody is proprietary information. Database link Q7Z2Y5
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Nik-related kinase (NRK) also known as MINK1 or Murine-inhibitor-of-apoptosis-protein-interacting-NK-1 is a protein kinase belonging to the germinal center kinase family. NRK has an approximate molecular mass of 195 kDa. This kinase expresses mostly in muscle tissues and the nervous system indicating its role in specific physiological processes related to these organs. NRK acts by phosphorylating target proteins which involves adding a phosphate group to specific serine or threonine residues influencing various signaling pathways.
- Biological function summary
Activities of NRK affect cell signaling and dynamic structural rearrangement. As part of larger protein complexes NRK interacts with other kinases to regulate cytoskeletal organization and cell morphology. NRK also has a role in embryonic development contributing to muscle formation and neuronal differentiation. This positioning in cellular processes marks NRK as an essential component in developmental biology and tissue-specific anatomical pathways.
- Pathways
NRK plays critical roles in signaling processes like the JNK/MAPK pathway. In this context NRK helps to mediate stress responses and apoptotic processes by interfacing with other kinases such as MKK4 and JNK1. NRK's activity influences cellular responses to environmental or cellular stress coordinating gene expression changes for appropriate cellular adaptation or apoptosis when necessary.
- Associated diseases and disorders
Alterations in NRK are linked to the development of certain cancers including colorectal cancer and neurodegenerative disorders like Alzheimer's disease. Changes in NRK expression or function can disrupt normal cellular signaling contributing to tumor progression or neural tissue degeneration. For instance deregulation of the NRK-JNK pathway may involve a crosstalk with proteins like Tau which plays a significant role in Alzheimer pathology highlighting NRK's importance in maintaining cellular homeostasis.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NRK antibody (ab224394)
Paraffin-embedded human placenta tissue stained for NRK using ab224394 at 1/200 dilution in immunohistochemical analysis.
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