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AB137193

Anti-NRL antibody

5

(1 Review)

|

(1 Publication)

Rabbit Polyclonal NRL antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NRL.

View Alternative Names

D14S46E, NRL, Neural retina-specific leucine zipper protein

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human NRL. The exact immunogen used to generate this antibody is proprietary information.

P54845

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NRL also known as Neural Retina Leucine zipper is a transcription factor weighing approximately 27 kDa. It plays a mechanical role in the regulation of gene expression specific to the retina. Predominantly expressed in the photoreceptor cells of the retina NRL is important for the development and maintenance of these cells. Its expression is tightly controlled during retinal differentiation particularly in rod photoreceptors where it dictates cellular development.
Biological function summary

NRL acts as an important regulator in photoreceptor cell differentiation and function. It forms complexes with other transcription factors such as CRX and NR2E3 to activate transcription of rod-specific genes. These complexes are important for the expression of genes necessary for phototransduction the process by which light is converted into electrical signals in the eyes. NRL's interactions target important retinal genes establishing its role as a determinant for rod versus cone cell fates.

Pathways

The activity of NRL is integrated into the phototransduction and retinoid metabolism pathways. Within these pathways NRL cooperates with other proteins like CRX and NR2E3 to control the expression of genes needed for rod photoreceptor function. NRL's orchestration of gene expression in these pathways assures the successful transduction of light signals and vitamin A recycling which are reactions critical for vision.

Mutations or dysfunctions in NRL are connected to retinal degenerative diseases like retinitis pigmentosa and Leber congenital amaurosis. In these conditions NRL's aberrant activity disrupts proper photoreceptor development leading to visual impairment. NRL's interactions with proteins such as CRX in these diseases are pivotal as mutations affecting these proteins also contribute to the pathogenesis highlighting the tight regulation required for correct retinal function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed : 21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed : 17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed : 17335001).
See full target information NRL
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Genetics in medicine : official journal of the American College of Medical Genetics 21:694-704 PubMed30072743

2018

Contribution of noncoding pathogenic variants to RPGRIP1-mediated inherited retinal degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Farzad Jamshidi,Emily M Place,Sudeep Mehrotra,Daniel Navarro-Gomez,Mathew Maher,Kari E Branham,Elise Valkanas,Timothy J Cherry,Monkol Lek,Daniel MacArthur,Eric A Pierce,Kinga M Bujakowska
View all publications
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Product promise

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