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AB237502

Anti-NRSN1/VMP antibody

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(1 Publication)

Rabbit Polyclonal NRSN1/VMP antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NRSN1 aa 1-100.

View Alternative Names

VMP, NRSN1, Neurensin-1, Neuro-p24, Vesicular membrane protein of 24 kDa, Vesicular membrane protein p24

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-NRSN1/VMP antibody (AB237502)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NRSN1/VMP antibody (AB237502)

HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for NRSN1/VMP (green) using ab237502 at 1/100 dilution in ICC/IF, followed by an Alexa Fluor®488 conjugated Goat Anti-Rabbit IgG (H+L).

Western blot - Anti-NRSN1/VMP antibody (AB237502)
  • WB

Supplier Data

Western blot - Anti-NRSN1/VMP antibody (AB237502)

All lanes:

Western blot - Anti-NRSN1/VMP antibody (ab237502) at 1/1000 dilution

Lane 1:

Mouse stomach lysate

Lane 2:

Mouse kidney lysate

Lane 3:

Mouse thymus lysate

Lane 4:

HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate

Lane 5:

HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 21 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human NRSN1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q8IZ57

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NRSN1/VMP also known as Neurensin-1 is a transmembrane protein with a molecular mass around 17 kDa. The protein predominantly expresses in neuronal tissues including the central and peripheral nervous systems. NRSN1 localizes to the membrane of small round vesicles where it appears to partake in vesicle trafficking due to its transmembrane nature.
Biological function summary

Neurensin-1 impacts neuronal development and function. It may be involved in synaptic plasticity and axonal transport although the exact biological functions are not fully extracted. Some studies suggest Neurensin-1 participates as part of a larger protein complex located in the neuronal growth cone thereby influencing cellular dynamics in neurons.

Pathways

Current data links Neurensin-1 to the endocytosis and nerve growth factor signaling pathways. These pathways are key to maintaining neuronal health and supporting neurogenesis. Neurensin-1 has demonstrated interactions with clathrin and dynamin essential proteins within these pathways revealing its importance in vesicle-mediated transport processes.

Neurensin-1 shows possible connections to neurodegenerative diseases such as Alzheimer's and Parkinson's. Neurensin-1 may influence these conditions through its interactions with proteins like amyloid-beta in Alzheimer's disease and alpha-synuclein in Parkinson's disease suggesting a role in pathological protein aggregation or clearance in neuronal cells.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity).
See full target information NRSN1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:10111 PubMed39578459

2024

Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuo Chen,Baocheng Wan,Hong Zhang,Lina Zhang,Rong Zhang,Lianxi Li,Yi Zhang,Cheng Hu
View all publications
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Product promise

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