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AB237739

Anti-NRSN2 antibody

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(3 Publications)

Rabbit Polyclonal NRSN2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NRSN2 aa 1-100.

View Alternative Names

C20orf98, NRSN2, Neurensin-2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-NRSN2 antibody (AB237739)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NRSN2 antibody (AB237739)

A549 (Human lung carcinoma cell line) cells stained for NRSN2 (green) using ab237739 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor®488-conjugated goat anti-rabbit IgG (H+L).

Western blot - Anti-NRSN2 antibody (AB237739)
  • WB

Supplier Data

Western blot - Anti-NRSN2 antibody (AB237739)

All lanes:

Western blot - Anti-NRSN2 antibody (ab237739) at 1/1000 dilution

All lanes:

Mouse liver tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 22 kDa,62 kDa

Observed band size: 34 kDa,68 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human NRSN2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9GZP1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NRSN2 also known as Neurensin-2 is a small protein with a mass of approximately 24 kDa. It is primarily expressed in the nervous system particularly in neurons. The protein has been observed in certain brain regions and neurons more intensely indicating a role in neural activities. As a transmembrane protein NRSN2 is involved in processes like vesicle trafficking and could influence neurotransmitter release.
Biological function summary

Neurensin-2 plays important roles in neuronal development and synaptic plasticity. It participates in cellular activities that influence neuron signaling and communication. While it does not form part of a larger protein complex it may interact with different cellular structures to regulate membrane dynamics. Such functions suggest its involvement in maintaining synaptic integrity and neuronal network stability important for proper nervous system function.

Pathways

Neurensin-2 is part of neural development and signaling pathways. It contributes significantly to pathways like synaptic transmission and intracellular trafficking integral for neuron communication and plasticity. Through these pathways Neurensin-2 relates to proteins like syntaxin which also influences vesicle docking and neurotransmitter release. These interactions highlight its role in facilitating synaptic connectivity and efficiency.

Neurensin-2 has links to neurodevelopmental disorders and neurodegenerative diseases. Mutations or dysregulation of NRSN2 activity may contribute to conditions like autism spectrum disorders or Alzheimer's disease. The protein has connections to tau proteins which are significant in Alzheimer's pathology indicating that disruptions in NRSN2 function could affect tau dynamics and aggregation. Understanding NRSN2's role may offer insights into potential therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in maintenance and/or transport of vesicles.
See full target information NRSN2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of cancer research and clinical oncology 150:214 PubMed38662050

2024

High core 1β1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Chen,Yanyan Ji,Lin Shen,Ying Li,Yue Ren,Hongcan Shi,Yue Li,Yunjiang Wu

Oncology letters 20:389 PubMed33193849

2020

Neurensin-2 promotes proliferation, invasion and migration of colorectal cancer cells via interaction with SOX12.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Wang,Kai Yang

Oncology letters 19:813-823 PubMed31885716

2019

NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF-κB signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Ren,Wei Zhang,Shuai Lu,Hong Ren,Yantong Guo
View all publications
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