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AB192313

Anti-NRXN3 antibody

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(1 Publication)

Rabbit Polyclonal NRX3A antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NRXN3.

View Alternative Names

C14orf60, KIAA0743, NRXN3, Neurexin-3, Neurexin III-alpha, Neurexin-3-alpha

1 Images
Western blot - Anti-NRXN3 antibody (AB192313)
  • WB

Supplier Data

Western blot - Anti-NRXN3 antibody (AB192313)

All lanes:

Western blot - Anti-NRXN3 antibody (ab192313)

Lane 1:

HeLa whole cell lysate

Lane 2:

Raw264.7 whole cell lysate

Lane 3:

H9C2 whole cell lysate

Predicted band size: 181 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human NRXN3. The exact immunogen used to generate this antibody is proprietary information.

Q9Y4C0

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Secondary Antibodies

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purity is > 95% (by SDS-PAGE).
Storage buffer
pH: 7.2 Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Neurexin 3 also known as NRXN3 is a member of the neurexin family of synaptic cell adhesion molecules. It weighs approximately 160 kDa. It is expressed widely in the brain where it plays a critical role in the connection between neurons. The NRXN3 protein helps establish and maintain synaptic connections facilitating communication in the nervous system. Different isoforms of NRXN3 generated through alternative splicing allow for diverse synaptic functions.
Biological function summary

The protein contributes to the formation of complex structures in synapses. NRXN3 interacts with neuroligins and other postsynaptic proteins forming a bridge across the synaptic cleft. This interaction is essential for the alignment and stabilization of pre- and postsynaptic formations influencing synaptic transmission. The NRXN3 complex enables specific synaptic architecture affecting both excitatory and inhibitory synapses.

Pathways

NRXN3 plays a role in key neural signaling routes. It participates in the synaptic formation and plasticity pathways being important for both synaptogenesis and synaptic maintenance. NRXN3 shares pathway interactions with proteins such as neuroligin and dystroglycan. This alignment is important for regulating synapse stabilization and may influence the release of neurotransmitters across synaptic junctions.

NRXN3 is linked to neurological conditions including autism spectrum disorders (ASD) and schizophrenia. Genetic variations in NRXN3 have been associated with synaptic dysfunction that can contribute to these conditions. It connects with proteins such as NRXN1 and neuroligins which are also implicated in similar neuropsychiatric disorders. Understanding NRXN3's involvement could aid in developing targeted therapies for these complex diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity).
See full target information NRXN3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell discovery 10:11 PubMed38291322

2024

Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.

Applications

Unspecified application

Species

Unspecified reactive species

Mengqi Lv,Wanwan Zhou,Yijie Hao,Fudong Li,Huafeng Zhang,Xuebiao Yao,Yunyu Shi,Liang Zhang
View all publications
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Product promise

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