Anti-NRXN3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Neurexin 3 also known as NRXN3 is a member of the neurexin family of synaptic cell adhesion molecules. It weighs approximately 160 kDa. It is expressed widely in the brain where it plays a critical role in the connection between neurons. The NRXN3 protein helps establish and maintain synaptic connections facilitating communication in the nervous system. Different isoforms of NRXN3 generated through alternative splicing allow for diverse synaptic functions.

Biological function summary

The protein contributes to the formation of complex structures in synapses. NRXN3 interacts with neuroligins and other postsynaptic proteins forming a bridge across the synaptic cleft. This interaction is essential for the alignment and stabilization of pre- and postsynaptic formations influencing synaptic transmission. The NRXN3 complex enables specific synaptic architecture affecting both excitatory and inhibitory synapses.

Pathways

NRXN3 plays a role in key neural signaling routes. It participates in the synaptic formation and plasticity pathways being important for both synaptogenesis and synaptic maintenance. NRXN3 shares pathway interactions with proteins such as neuroligin and dystroglycan. This alignment is important for regulating synapse stabilization and may influence the release of neurotransmitters across synaptic junctions.

Associated diseases and disorders

NRXN3 is linked to neurological conditions including autism spectrum disorders (ASD) and schizophrenia. Genetic variations in NRXN3 have been associated with synaptic dysfunction that can contribute to these conditions. It connects with proteins such as NRXN1 and neuroligins which are also implicated in similar neuropsychiatric disorders. Understanding NRXN3's involvement could aid in developing targeted therapies for these complex diseases.