Anti-NSUN6 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NSUN6 also known as NOP2/Sun RNA methyltransferase family member 6 is an RNA-modifying enzyme. It belongs to the NOL1/NOP2/Sun family and is responsible for catalyzing 5-methylcytosine formation on target RNA molecules playing an important role in RNA modification. The molecular mass of NSUN6 is approximately 56 kDa. It is expressed in various tissues but shows higher expression in the liver and skeletal muscle suggesting a potential specialization in these areas.

Biological function summary

NSUN6 contributes to the regulation of cellular processes by modifying RNA molecules. It is not currently identified as part of any known protein complex but significantly influences the stability and function of specific RNA targets. By this action NSUN6 can indirectly affect gene expression and downstream biological activities which might be critical during cellular growth and differentiation.

Pathways

NSUN6 interacts closely with pathways related to RNA processing and modification. It contributes to the epitranscriptomic landscape working alongside proteins such as NSUN2 another methyltransferase to maintain RNA modification balance. This activity impacts broader pathways like those regulating gene expression and protein synthesis exhibiting an interconnected role in fundamental cellular activities.

Associated diseases and disorders

NSUN6 shows relevance to cancer and neurodevelopmental disorders. Alterations in its normal function could disrupt RNA methylation patterns leading to aberrant gene expression linked to these conditions. NSUN6's functional relationship with NSUN2 another RNA methyltransferase suggests that disruptions in their balance might contribute to these disorders highlighting their potential as targets for therapeutic intervention.