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AB150437

Anti-NT-4 antibody [EPR9180]

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(2 Publications)

Rabbit Recombinant Monoclonal NT-4 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.

View Alternative Names

NTF5, NTF4, Neurotrophin-4, NT-4, Neurotrophin-5, Neutrophic factor 4, NT-5

1 Images
Western blot - Anti-NT-4 antibody [EPR9180] (AB150437)
  • WB

Unknown

Western blot - Anti-NT-4 antibody [EPR9180] (AB150437)

All lanes:

Western blot - Anti-NT-4 antibody [EPR9180] (ab150437) at 1/1000 dilution

Lane 1:

Human prostate cancer tissue lysate at 10 µg

Lane 2:

Human stomach tissue lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP labelled antibody at 1/2000 dilution

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9180

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NT-4 also known as Neurotrophin-4 is a member of the neurotrophin family of proteins. It has a molecular mass of around 14 kDa. NT-4 is expressed in both the central and peripheral nervous systems with significant presence in the brain particularly in regions such as the cortex and hippocampus. This protein acts through binding to the TrkB receptor and plays a direct role in supporting neuronal survival and differentiation.
Biological function summary

NT-4 regulates the growth and maturation of neurons. It is a part of the neurotrophin signaling complex which includes other family members like brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). By promoting axonal growth and synaptic plasticity NT-4 influences both embryonic neurodevelopment and adult neural adaptations. Its functions are important for maintaining the health of neurons and overall brain function.

Pathways

NT-4 is involved in the neurotrophin signaling pathway and MAPK pathway. It interacts with the TrkB receptor to activate signaling cascades that regulate neuronal survival and plasticity. In these pathways proteins like PIK3CA and MAPK1 interact with NT-4 facilitating its role in signal transduction that influences neural activities and responses to external stimuli.

NT-4 is linked to neurological conditions such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). In Alzheimer's disease NT-4 in association with BDNF influences neuronal survival and synaptic maintenance which are often compromised as the disease progresses. In ALS interactions between NT-4 and TrkB receptors may affect motor neuron health and survival therefore playing a role in disease pathology. Understanding these relationships can shed light on potential therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Target-derived survival factor for peripheral sensory sympathetic neurons (PubMed : 1742028). May promote ameloblast differentiation and subsequent reduction in proliferation of ameloblasts (By similarity).
See full target information NTF4
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:18912 PubMed40442166

2025

Uncovering the molecular mechanisms of tonifying kidney and activating blood Decoction against myocardial fibrosis using network Pharmacology and experimental validation.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Xu,Yanping Bi,Yetao Ju,Wenhao Yin,Shujun Zhao,Yan Zhang,Xin Zhao

Contrast media & molecular imaging 2022:9078012 PubMed36034210

2022

The Role of Neurotrophin-4/Forkhead Box L1 in the Development of Nonsmall-Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Mu,Hong Zhao,Yifeng Zhang,Chun Xiao
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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