Anti-Nuclear Matrix Protein p84 antibody [EPR5661]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Nuclear Matrix Protein p84 also known as 5E10 or simply p84 is a structural protein of the nuclear matrix. It has an approximate mass of 84 kDa. Researchers have identified it as an integral component of the nucleoskeleton providing key structural support within the cell nucleus. The expression of p84 is resourceful within various cell types especially in tissues with high rates of cellular proliferation and turnover.

Biological function summary

Nuclear Matrix Protein p84 assists in nuclear architecture maintenance and organization. It takes part in DNA replication processes and gene regulation by interacting with chromatin and transcription factors. Furthermore p84 contributes to the formation of the ribonucleoprotein complex facilitating RNA processing and transport. This involvement in multiple nuclear tasks positions it as a critical player in gene expression regulation mechanisms.

Pathways

Nuclear Matrix Protein p84 influences vital cellular activities such as the cell cycle and DNA repair. Its connections are apparent in the regulation of the p53 signaling pathway where it interacts with several regulatory proteins to monitor cell cycle progression and stress responses. p84’s activity also aligns with the DNA damage response pathway highlighting its cooperation with checkpoint proteins like ATM and ATR that uphold genomic integrity during cellular stress conditions.

Associated diseases and disorders

Aberrant Nuclear Matrix Protein p84 expression aligns with cancer and autoimmune conditions. In certain cancers deregulation of p84 can result in altered cell cycle control and resistance to apoptosis. Its interaction with p53 and other tumor suppressor proteins directly influences cancer cell survival and proliferation. Additionally altered p84 expression has connections to lupus specifically affecting the autoantigen properties and leading to immune system malfunctions. Understanding these connections helps scientists investigate therapeutic targets for associated diseases.