AB140651

Anti-Nucleoporin p62/NUP62 antibody [EPR9919]

RabMAb
Recombinant
What is this?

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(6 Publications)

Rabbit Recombinant Monoclonal Nucleoporin p62/NUP62 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications.

View Alternative Names

Nuclear pore glycoprotein p62, 62 kDa nucleoporin, Nucleoporin Nup62, NUP62

1 Images

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Western blot - Anti-Nucleoporin p62/NUP62 antibody [EPR9919] (AB140651)

All lanes:

Western blot - Anti-Nucleoporin p62/NUP62 antibody [EPR9919] (ab140651) at 1/10000 dilution

Lane 1:

HepG2 cell lysates at 10 µg

Lane 2:

Raji cell lysates at 10 µg

Secondary

All lanes:

HRP conjugated goat anti-rabbit at 1/2000 dilution

Predicted band size: 53 kDa

false

Carrier free

Anti-Nucleoporin p62/NUP62 antibody [EPR9919] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR9919

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Conditional Ambient

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Nucleoporin p62 also known as NUP62 plays a significant role in transporting molecules across the nuclear envelope. This protein is a part of the nuclear pore complex which acts as a gateway for nucleocytoplasmic exchange. NUP62 has a molecular weight of approximately 62 kDa. It is expressed in the cell nucleus particularly at the nuclear envelope where it helps in the regulation of macromolecular traffic between the nucleus and cytoplasm.

Biological function summary

NUP62 is essential for maintaining the normal function of the nuclear pore complex. It forms a soluble subcomplex with other nucleoporins facilitating nuclear pore assembly. This protein contributes to the dynamic nature of the nuclear porins ensuring efficient and selective transport. NUP62 also interacts directly with nucleic acids and other transport receptors allowing for the precise regulation of nuclear-cytoplasmic exchange processes.

Pathways

NUP62 takes part in critical transport pathways such as the karyopherin-mediated import and export processes. It collaborates with importin-beta a transport receptor that binds to nuclear localization signals on cargo proteins. Through these pathways NUP62 ensures that essential proteins and RNAs are correctly swapped between the nucleus and the rest of the cell playing an important role in cellular homeostasis and gene expression regulation.

Defects in NUP62 have been linked to conditions like neurodegenerative diseases and certain cancers. Anomalies in its function can disrupt normal cellular communication and lead to pathological states. NUP62 interacts with proteins implicated in these conditions such as amyloid precursor protein in Alzheimer's disease indicating its importance in neuronal function. In cancer altered expression of NUP62 can contribute to the dysregulation of gene expression which is a hallmark of tumorigenesis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Essential component of the nuclear pore complex (PubMed : 1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed : 1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed : 1915414, PubMed : 24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed : 24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed : 24107630).

See full target information NUP62

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

International journal of oral science 17:34 PubMed40246825

2025

NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming.

Applications

Unspecified application

Species

Unspecified reactive species

Xiping Wang,Li Wang,Linxi Zhou,Lu Chen,Jiayi Shi,Jing Ge,Sha Tian,Zihan Yang,Yuqiong Zhou,Qihao Yu,Jiacheng Jin,Chen Ding,Yihuai Pan,Duohong Zou

The international journal of neuropsychopharmacology 27: PubMed39099166

2024

Identification of Phosphodiesterase-7A (PDE7A) as a Novel Target for Reducing Ethanol Consumption in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ran Wei,Fangjiao Zong,Jiahao Dong,Wei Zhao,Fangfang Zhang,Wei Wang,Shuang Zhao,Ziqi Wang,Fang Zhang,Han-Ting Zhang

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2302677 PubMed37387563

2023

Small Extracellular Vesicle-Derived vWF Induces a Positive Feedback Loop between Tumor and Endothelial Cells to Promote Angiogenesis and Metastasis in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Samuel Wan Ki Wong,Sze Keong Tey,Xiaowen Mao,Hiu Ling Fung,Zhi-Jie Xiao,Danny Ka Ho Wong,Lung-Yi Mak,Man-Fung Yuen,Irene Oi-Lin Ng,Jing Ping Yun,Yi Gao,Judy Wai Ping Yam

Food science & nutrition 11:1965-1981 PubMed37051356

2023

lncRNA TINCR knockdown inhibits colon cancer cells via regulation of autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Jianhua Xu,Wenge Zeng,Tiantian Liu,Zhenda Wan,Xin Yang,Jun Chen,Fei Liu

Molecular therapy. Nucleic acids 30:30-47 PubMed36189423

2022

Functional high-throughput screen identifies microRNAs that promote butyrate-induced death in colorectal cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Saira R Ali,Karen J Humphreys,Kaylene J Simpson,Ross A McKinnon,Robyn Meech,Michael Z Michael

Bioengineered 13:4051-4062 PubMed35129051

2022

Columbianetin alleviates lipopolysaccharides (LPS)-induced inflammation and apoptosis in chondrocyte through activation of autophagy by inhibiting serum and glucocorticoid-induced protein kinase 1 (SGK1) expression.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Chen,Haotian Zheng,Xuan Zhang,Yude Xu,Zhibin Fu,Xing Ji,Changhao Wei,Guoyao An,Mingyuan Tan,Mingwang Zhou

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Nucleoporin p62/NUP62 antibody [EPR9919]

Western blot - Anti-Nucleoporin p62/NUP62 antibody [EPR9919] (AB140651)

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Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

Product promise