Anti-Nucleoprotein Crimean-Congo hemorrhagic fever virus antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Nucleoprotein of the Crimean-Congo hemorrhagic fever virus (CCHFV) acts as an important structural component of the viral particle. It is also known as NP or N protein. This protein is responsible for packaging the viral RNA genome stabilizing it and protecting it from degradation. With an estimated mass of around 50 kDa the nucleoprotein expresses itself within infected host cells particularly in the cytoplasm where viral replication occurs. The protein's role in the viral lifecycle makes it a significant focus for antiviral research.

Biological function summary

The Nucleoprotein of CCHFV plays a critical role in viral replication and assembly. It participates in the formation of the ribonucleoprotein complex which is important for viral RNA synthesis and replication. In this process the nucleoprotein interacts closely with the viral polymerase and other viral proteins to coordinate the replication process within the host cell. By binding the RNA genome it ensures efficient packaging of the RNA into new virion particles enabling successful viral dissemination.

Pathways

The Nucleoprotein functions involve intracellular processes that impact the host's immune response pathways. It modulates pathways related to the host's antiviral response such as the interferon signaling pathway. By interacting with proteins like viral polymerase it may play roles that affect the host's ability to detect and respond to viral infection. These interactions help the virus to evade immune detection supporting its survival and propagation within the host.

Associated diseases and disorders

The Nucleoprotein relates to the pathogenesis of Crimean-Congo hemorrhagic fever. This viral protein is directly linked to the severity of the disease influencing the viral load and immune response in infected individuals. Additionally connections exist between the Nucleoprotein and other viral proteins like the glycoproteins that together contribute to the pathogenic mechanisms causing high mortality in hemorrhagic fever cases. Understanding the role of the Nucleoprotein is critical for developing targeted therapies and vaccines against this severe disease.