Anti-NUDT12 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

NUDT12 also known as Nudix hydrolase 12 plays a role in hydrolyzing nucleoside diphosphates. It mainly acts on ADP-ribose a product from NAD+ metabolism. The molecular mass of NUDT12 is approximately 43 kDa. Expression of NUDT12 occurs significantly in liver tissues and to some extent in other tissues as well. It contributes to maintaining nucleotide pools ensuring cellular homeostasis by freeing the cells from non-canonical nucleotides that can be harmful.

Biological function summary

NUDT12 regulates cellular functions by processing NAD+ metabolites. It forms part of a complex involved with enzymes that manage nucleotide hydrolysis. By removing non-standard nucleotides from the internal environment it prevents harmful incorporation into nucleic acids. Its activity supports processes like DNA repair safeguarding genome integrity which is important for normal cell function.

Pathways

NUDT12 functions within NAD+ metabolism and the nucleotide salvage pathway. It is part of a group of Nudix hydrolases that includes proteins like NUDT1. These proteins collectively aid in nucleotide management and energy homeostasis. By collaborating in these pathways NUDT12 ensures metabolic processes proceed without interference from aberrant molecules.

Associated diseases and disorders

Dysfunction in NUDT12 is linked to conditions related to metabolic imbalance such as metabolic syndrome and certain liver diseases. This is due to its role in managing nucleotide pools a process implicated in the pathology of these disorders. Connections between NUDT12 and proteins like PARP which is involved in DNA repair and epigenetic regulation highlight its potential impact on disease mechanisms where NAD+ and its derivatives play roles.