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AB59770

Anti-NUFIP1 antibody [2662C1a]

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(1 Publication)

Mouse Monoclonal NUFIP1 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NUFIP1.

View Alternative Names

FMR1-interacting protein NUFIP1, Nuclear FMR1-interacting protein 1, Nuclear FMRP-interacting protein 1, NUFIP1

1 Images
Western blot - Anti-NUFIP1 antibody [2662C1a] (AB59770)
  • WB

Unknown

Western blot - Anti-NUFIP1 antibody [2662C1a] (AB59770)

All lanes:

Western blot - Anti-NUFIP1 antibody [2662C1a] (ab59770)

All lanes:

immunizing peptide

Predicted band size: 56 kDa

Observed band size: 40 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

2662C1a

Isotype

IgG1

Carrier free

No

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human NUFIP1. The exact immunogen used to generate this antibody is proprietary information.

Q9UHK0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Filtered through a 0.22 µm membrane.
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NUFIP1 or Nuclear Fragile X Mental Retardation Interacting Protein 1 functions as an important component in ribosome biogenesis. It has a molecular mass of approximately 90 kDa. This protein interacts with ribosomal RNA and facilitates the stabilization of the 90S pre-ribosomal particle. NUFIP1 exists in multiple cellular compartments including the nucleolus which indicates its role in ribosome assembly and processing within the nuclear environment.
Biological function summary

NUFIP1 contributes to the maturation of ribosomal RNA as part of the ribonucleoprotein complex specifically the box C/D snoRNP complex. Its involvement in the assembly of ribosomal components is essential for the proper synthesis of ribosomes. NUFIP1's role in snoRNPs suggests it participates in chemical modifications on rRNA most notably methylation a critical modification in the ribosome's function.

Pathways

NUFIP1 actively participates in the ribosome biogenesis in the nucleolus and cytosolic ribosome pathways. It interacts closely with partner proteins like SURF6 and NOP58 which are critical components in these pathways. These interactions ensure the proper production and function of ribosomes ensuring effective cellular protein synthesis.

Researchers have linked abnormalities in NUFIP1 to disorders such as Fragile X syndrome and cancer. In Fragile X syndrome its interaction with the fragile X mental retardation protein (FMRP) highlights its importance in neuronal development. In cancer dysregulation in ribosome synthesis where NUFIP1 is involved can lead to uncontrolled cell growth illustrating its potential role in tumorigenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds RNA.
See full target information NUFIP1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BioMed research international 2022:6918396 PubMed35909488

2022

hsa_circ_0084811 Regulates Cell Proliferation and Apoptosis in Retinoblastoma through miR-18a-5p/miR-18b-5p/E2F5 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Guangwei Jiang,Mingxuan Qu,Lili Kong,Xiaoming Song,Shanhao Jiang
View all publications
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Product promise

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