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AB73290

Anti-Nup107 antibody

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(5 Publications)

Rabbit Polyclonal Nup107 antibody. Suitable for ICC, WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human Nuclear pore complex protein Nup107.

View Alternative Names

Nuclear pore complex protein Nup107, 107 kDa nucleoporin, Nucleoporin Nup107, NUP107

3 Images
Immunocytochemistry - Anti-Nup107 antibody (AB73290)
  • ICC

Unknown

Immunocytochemistry - Anti-Nup107 antibody (AB73290)

ab73290 at 10μg/ml staining Nup107 in A549 cells by Immunocytochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-Nup107 antibody (AB73290)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Nup107 antibody (AB73290)

Immunofluorescence of NUP107 in A549 cells using ab73290 at 10 ug/ml.

Western blot - Anti-Nup107 antibody (AB73290)
  • WB

Unknown

Western blot - Anti-Nup107 antibody (AB73290)

Lane 1:

Western blot - Anti-Nup107 antibody (ab73290) at 1 µg/mL

Lane 2:

Western blot - Anti-Nup107 antibody (ab73290) at 2 µg/mL

All lanes:

A549 cell lysate at 15 µg

Predicted band size: 106 kDa

Observed band size: 194 kDa,95 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC, ICC/IF

applications

Immunogen

Synthetic Peptide within Human Nuclear pore complex protein Nup107. The exact immunogen used to generate this antibody is proprietary information.

P57740

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "10 µg/mL", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Nup107 also known as nucleoporin 107 is an important protein component of the nuclear pore complex (NPC). With a molecular mass of approximately 107 kDa it is a significant element in the structure of the NPC. Nup107 is expressed in various tissues throughout the body. It plays an essential mechanical role in the assembly and maintenance of NPCs facilitating the transport of macromolecules between the nucleus and the cytoplasm.
Biological function summary

Nup107 forms part of the Nup107-160 subcomplex which contributes to the NPC's structural integrity and function. This complex acts as a scaffold providing support for the overall architecture and positioning within the nuclear envelope. The presence of Nup107 influences nuclear-cytoplasmic transport which is key in regulation of gene expression and cell cycle progression. Nup107 ensures proper assembly serving as an anchor for other nucleoporins within the NPC.

Pathways

The Nup107 subcomplex plays a critical role in key cellular processes such as the cell cycle and gene expression regulation. It participates in the mitotic entry and exit by regulating nucleocytoplasmic transport of cell cycle regulators and transcription factors. Nup107 interacts with proteins like Nup133 and Nup160 which assist in these processes. The precise functioning of Nup107 is necessary for maintaining cellular homeostasis and successful progression through cell division.

Nup107 has links to conditions such as primary ovarian insufficiency and nephrotic syndrome. Mutations or aberrant expression of Nup107 disrupt NPC assembly or function potentially leading to impaired cellular transport and altered cellular functions. In ovarian insufficiency altered Nup107 expression affects folliculogenesis by disrupting nuclear transport of specific factors. In nephrotic syndrome Nup107 dysfunction impacts the glomerular filtration barrier with associated proteins like nephrin and podocin demonstrating interrelated pathological effects.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed : 12552102, PubMed : 15229283, PubMed : 30179222). Required for the assembly of peripheral proteins into the NPC (PubMed : 12552102, PubMed : 15229283). May anchor NUP62 to the NPC (PubMed : 15229283). Involved in nephrogenesis (PubMed : 30179222).
See full target information Nuclear pore complex protein Nup107
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Gynecologic and obstetric investigation 85:41-52 PubMed31487736

2019

Nucleoporin 107 Promotes the Survival of Tumor Cells in Cervical Cancers.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Shi,Liang Xu,Li Huang,Jing-Xin Cheng

The Journal of cell biology 218:2962-2981 PubMed31375530

2019

Imaging within single NPCs reveals NXF1's role in mRNA export on the cytoplasmic side of the pore.

Applications

Unspecified application

Species

Unspecified reactive species

Rakefet Ben-Yishay,Amir Mor,Amit Shraga,Asaf Ashkenazy-Titelman,Noa Kinor,Avital Schwed-Gross,Avi Jacob,Noga Kozer,Pramod Kumar,Yuval Garini,Yaron Shav-Tal

Neuron 102:339-357.e7 PubMed30853299

2019

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death.

Applications

Unspecified application

Species

Unspecified reactive species

Fatima Gasset-Rosa,Shan Lu,Haiyang Yu,Cong Chen,Ze'ev Melamed,Lin Guo,James Shorter,Sandrine Da Cruz,Don W Cleveland

Journal of cellular and molecular medicine 23:1448-1457 PubMed30506890

2018

Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Guan,Xueting Gao,Qiuyu Tang,Lin Huang,Siyun Gao,Shuai Yu,Jiale Huang,Jun Li,Daizhan Zhou,Yangyang Zhang,Dan Shi,Dandan Liang,Yi Liu,Li Li,Yingyu Cui,Liang Xu,Yi-Han Chen

eLife 7: PubMed30084827

2018

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.

Applications

Unspecified application

Species

Unspecified reactive species

Melissa Kane,Stephanie V Rebensburg,Matthew A Takata,Trinity M Zang,Masahiro Yamashita,Mamuka Kvaratskhelia,Paul D Bieniasz
View all publications
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