JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB73293

Anti-NUP160 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal NUP160 antibody. Suitable for WB and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NUP160.

View Alternative Names

KIAA0197, NUP120, NUP160, Nuclear pore complex protein Nup160, 160 kDa nucleoporin, Nucleoporin Nup160

1 Images
Western blot - Anti-NUP160 antibody (AB73293)
  • WB

Unknown

Western blot - Anti-NUP160 antibody (AB73293)

Lane 1:

Western blot - Anti-NUP160 antibody (ab73293) at 0.5 µg/mL

Lane 2:

Western blot - Anti-NUP160 antibody (ab73293) at 1 µg/mL

All lanes:

rat brain tissue lysate at 15 µg

Predicted band size: 162 kDa

Observed band size: 160 kDa,70 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human NUP160. The exact immunogen used to generate this antibody is proprietary information.

Q12769

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NUP160 also known as nucleoporin 160 is a component of the nuclear pore complex (NPC). It has a molecular mass of approximately 160 kDa. NUP160 is expressed in many types of cells throughout the body particularly in the nuclear envelope where it plays a role in nucleo-cytoplasmic transport. NUP160 forms a part of the structural scaffold of the nuclear pore complex which is essential for the transport of molecules between the nucleus and the cytoplasm.
Biological function summary

NUP160 plays an important function in the regulation of RNA and protein transport across the nuclear envelope. This protein is a part of the Y-complex an important structural component of the nuclear pore complex consisting of multiple nucleoporins. NUP160 contributes to the assembly and maintenance of the pore. By facilitating the controlled exchange of macromolecules NUP160 helps maintain cellular homeostasis and the flow of genetic information.

Pathways

NUP160 is critically involved in nucleocytoplasmic transport and gene expression regulation. It plays a significant role in the transport pathway where it interacts with importins and exportins proteins that mediate the transport of cargo molecules through the nuclear pore complex. NUP160 also links to the Ran GTPase cycle an important process for directional transport by working with related proteins like RanBP2.

NUP160 is associated with nephrotic syndrome and cancer. Abnormal expression or mutations in NUP160 and the related protein NUP93 have been observed in cases of steroid-resistant nephrotic syndrome affecting kidney function. Additionally alterations in NUP160 expression can influence oncogenesis as the protein's disruption could lead to faulty nucleocytoplasmic transport contributing to cancer progression. Understanding the connection between NUP160 and these diseases can offer insights into potential therapeutic targets.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Functions as a component of the nuclear pore complex (NPC) (PubMed : 11564755, PubMed : 11684705). Involved in poly(A)+ RNA transport.
See full target information NUP160
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:3782 PubMed37355754

2023

The HIV-1 capsid core is an opportunistic nuclear import receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Guangai Xue,Hyun Jae Yu,Cindy Buffone,Szu-Wei Huang,KyeongEun Lee,Shih Lin Goh,Anna T Gres,Mehmet Hakan Guney,Stefan G Sarafianos,Jeremy Luban,Felipe Diaz-Griffero,Vineet N KewalRamani

Regenerative therapy 21:87-95 PubMed35785044

2022

NUP160 knockdown inhibits the progression of diabetic nephropathy and .

Applications

Unspecified application

Species

Unspecified reactive species

Jiayong Xie,Zhi Chen,Gang Yao,Ying Yuan,Wenjuan Yu,Qiang Zhu
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB16663

Anti-Cyclin D1 antibody [SP4]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials

Western blot - Anti-Cyclin D1 antibody [SP4] (AB16663)

  • 4
  • 23
Primary Antibodies

AB199728

Anti-Cdk4 antibody [EPR17525]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Cdk4 antibody [EPR17525] (AB199728)

  • 0
  • 0
Primary Antibodies

AB32034

Anti-p27 KIP 1 antibody [Y236]

KO Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p27 KIP 1 antibody [Y236] (AB32034)

  • 4
  • 18

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com