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AB204490

Anti-NUP188 antibody

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(2 Publications)

Rabbit Polyclonal NUP188 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NUP188 aa 250-400.

View Alternative Names

KIAA0169, NUP188, Nucleoporin NUP188, hNup188

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-NUP188 antibody (AB204490)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NUP188 antibody (AB204490)

Immunofluorescent analysis of paraformaldehyde-fixed SiHa cells labeling NUP188 using ab204490 at 4 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUP188 antibody (AB204490)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUP188 antibody (AB204490)

Immunohistochemical analysis of paraffin-embedded Human endometrium tissue labeling NUP188 using ab204490 at a 1/20 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human NUP188 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.

Q5SRE5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NUP188 protein also known as nucleoporin 188 is a core component of the nuclear pore complex (NPC). It has a molecular mass of approximately 188 kDa. This protein is expressed in various tissues where it contributes to the structure and function of the NPC which is essential for the transport of molecules between the nucleus and cytoplasm. NUP188 interacts directly with other nucleoporins to form the intricate architecture of the NPC facilitating the regulation of nucleocytoplasmic exchange.
Biological function summary

NUP188 plays a critical role in maintaining the integrity of the nuclear envelope. It is an integral part of the nuclear pore complex joining together with other proteins to ensure the selective transport of macromolecules. NUP188 contributes to the regulation of gene expression and cell cycle progression by mediating nucleoplasmic communication. Its presence in the NPC structure ensures that the necessary components for DNA replication and repair can pass through the nuclear envelope.

Pathways

NUP188 is involved in important cellular transport pathways such as the nucleo-cytoplasmic transport pathway. This pathway includes other nucleoporins like NUP93 and NUP205 which work with NUP188 to facilitate the movement of proteins and RNA. The precise regulation of these pathways supports functions like RNA processing and ribosomal biogenesis ensuring proper cellular operation and survival.

Disruptions in NUP188 function have associations with cancer and neurodegenerative diseases. Altered expression or mutation of NUP188 can lead to changes in the nucleocytoplasmic transport mechanism potentially contributing to tumorigenesis or the progression of neurological conditions. Its interaction with other nucleoporins like NUP93 in these contexts highlights the potential for broad effects on cellular homeostasis making it significant in the study of related pathologies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed : 32275884).
See full target information NUP188
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 16:1586784 PubMed40861463

2025

The value of nucleoporin 188 in diagnosis, prognosis and immunoregulation: from pan-cancer analysis to gastric cancer verification.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengfeng Zhu,Ru Peng,Huanhuan Cai

Anatomical record (Hoboken, N.J. : 2007) 305:209-221 PubMed34041863

2021

Outer and inner mitochondrial membrane proteins TOMM40 and TIMM50 are intensively concentrated and localized at Purkinje and pyramidal neurons in the New Zealand white rabbit brain.

Applications

Unspecified application

Species

Unspecified reactive species

Sameh M Farouk,Ahmed M Abdellatif,Elsayed Metwally
View all publications
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Product promise

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