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AB220890

Anti-NUP54 antibody

0

(1 Review)

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(3 Publications)

Rabbit Polyclonal NUP54 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Nucleoporin p54 aa 50-200.

View Alternative Names

Nucleoporin p54, 54 kDa nucleoporin, NUP54

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-NUP54 antibody (AB220890)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NUP54 antibody (AB220890)

Immunofluorescent analysis of PFA fixed, triton X-100 permeabilized U-2 OS cells labeling NUP54 using ab220890 at 4 μg/mL (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human Nucleoporin p54 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q7Z3B4

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Alternative Products

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Primary Antibodies

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Primary Antibodies

AB137092

Anti-NUP50 antibody [EPR9526]

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Immunocytochemistry/ Immunofluorescence - Anti-NUP50 antibody [EPR9526] (AB137092)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NUP54 also known as Nuclear Pore Complex Protein Nup54 or nucleoporin 54kDa functions as a part of the nuclear pore complex (NPC) a structure facilitating the transport of molecules across the nuclear envelope. This protein has a molecular mass of approximately 54 kDa and is ubiquitously expressed in eukaryotic cells. NUP54 is integral to the assembly and stability of the NPC and it assists in the regulation of nucleocytoplasmic transport by acting as a structural component within the pore.
Biological function summary

NUP54 plays an important role in the movement of proteins and RNA due to its position within the nuclear pore complex. Acting as a pivotal component of the NPC NUP54 interacts with other nucleoporins to form a selective barrier that controls the bidirectional movement of molecules. Proteins such as NUP62 and NUP58 are also part of this complex working alongside NUP54 to ensure efficient transport processes necessary for cell function and regulation.

Pathways

NUP54 is significantly involved in the protein and mRNA export pathways essential steps for cellular communication and regulation. It ensures the proper translocation of molecules through the nuclear pore working closely with other proteins such as importins and exportins within these pathways. NUP54's involvement in these pathways highlights its importance in maintaining cellular homeostasis and facilitating signal transduction from the nucleus to the cytoplasm.

NUP54 has connections to specific conditions such as neurodegenerative diseases and cancer. Mutations or dysregulation in NUP54 can lead to altered nucleocytoplasmic transport potentially contributing to the pathogenesis of neurodegenerative diseases. In cancer NUP54 may influence tumor progression through its interactions with other nucleoporins like NUP214 which is frequently overexpressed or rearranged in various tumor types. Understanding NUP54's role in these diseases could provide insights for therapeutic targeting.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
See full target information Nucleoporin p54
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 23:96 PubMed39966859

2025

REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojing Ren,Yunfei Teng,Kunxin Xie,Xiao He,Gang Chen,Kaini Zhang,Qingyi Liao,Jia Zhang,Xiaohang Zhou,Yating Zhu,Wenyu Song,Yuege Lin,Yi Zhang,Zhijian Xu,Noriaki Maeshige,Xiubin Liang,Dongming Su,Peng Sun,Ying Ding

Nature communications 13:3380 PubMed35697676

2022

NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.

Applications

Unspecified application

Species

Unspecified reactive species

Amanda M Gleixner,Brandie Morris Verdone,Charlton G Otte,Eric N Anderson,Nandini Ramesh,Olivia R Shapiro,Jenna R Gale,Jocelyn C Mauna,Jacob R Mann,Katie E Copley,Elizabeth L Daley,Juan A Ortega,Maria Elena Cicardi,Evangelos Kiskinis,Julia Kofler,Udai B Pandey,Davide Trotti,Christopher J Donnelly

Neuron 107:1124-1140.e11 PubMed32673563

2020

GC Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.

Applications

Unspecified application

Species

Unspecified reactive species

Alyssa N Coyne,Benjamin L Zaepfel,Lindsey Hayes,Boris Fitchman,Yuval Salzberg,En-Ching Luo,Kelly Bowen,Hannah Trost,Stefan Aigner,Frank Rigo,Gene W Yeo,Amnon Harel,Clive N Svendsen,Dhruv Sareen,Jeffrey D Rothstein
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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