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AB53750

Anti-NUP93 antibody [3332C2a]

5

(1 Review)

|

(6 Publications)

Mouse Monoclonal NUP93 antibody. Suitable for WB and reacts with Recombinant fragment samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NUP93.

View Alternative Names

KIAA0095, NUP93, Nuclear pore complex protein Nup93, 93 kDa nucleoporin, Nucleoporin Nup93

1 Images
Western blot - Anti-NUP93 antibody [3332C2a] (AB53750)
  • WB

Unknown

Western blot - Anti-NUP93 antibody [3332C2a] (AB53750)

All lanes:

Western blot - Anti-NUP93 antibody [3332C2a] (ab53750)

All lanes:

Recombinant immunising protein fragment

Predicted band size: 93 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

3332C2a

Isotype

IgG1

Carrier free

No

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human NUP93. The exact immunogen used to generate this antibody is proprietary information.

Q8N1F7

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NUP93 also known as nucleoporin 93 is a protein with a molecular mass of approximately 93 kDa. It forms a part of the nuclear pore complex (NPC) specifically contributing to its structural integrity. NUP93 can be found in the nuclear envelope of eukaryotic cells where it aids in the proper functioning of the NPC. The protein ensures that macromolecules can efficiently transport between the nucleus and the cytoplasm therefore maintaining cellular function.
Biological function summary

NUP93 plays an important role in the assembly and stability of the nuclear pore complex by interacting with other nucleoporins. It is a component of the core scaffold structure interacting with proteins like NUP205 and NUP188 and helps in the spatial arrangement and functionality within the complex. Through these interactions NUP93 contributes to selective transport acting as gatekeeper to regulate traffic into and out of the nucleus.

Pathways

NUP93 influences various cellular processes by affecting nuclear transport pathways such as the nucleocytoplasmic transport pathway. Through its connectivity in the nuclear pore complex it affects the transit of molecules like messenger RNA (mRNA) and ribonucleoprotein complexes. NUP93 is associated with proteins such as importin-beta which is involved in the import of proteins with nuclear localization signals thereby ensuring precise nuclear-cytoplasmic communication.

Mutations or dysregulation of NUP93 have associations with nephrotic syndrome and some forms of cancer. Nephrotic syndrome can result from altered nuclear pore function where NUP93 links with proteins like podocin affecting kidney filtration efficiency. In cancer changes in nuclear transport potentially involving interactions with oncogenic proteins can disrupt cell cycle regulation and contribute to tumorogenic processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed : 9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed : 26878725).
See full target information NUP93
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Nature protocols 20:26-66 PubMed39304762

2024

Rapid generation of homozygous fluorescent knock-in human cells using CRISPR-Cas9 genome editing and validation by automated imaging and digital PCR screening.

Applications

Unspecified application

Species

Unspecified reactive species

Andrea Callegari,Moritz Kueblbeck,Natalia Rosalía Morero,Beatriz Serrano-Solano,Jan Ellenberg

Frontiers in endocrinology 12:757592 PubMed34975746

2021

Sperm Proteome Analysis to Investigate DNA Repair Mechanisms in Varicocele Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Renata Finelli,Sara Darbandi,Peter Natesan Pushparaj,Ralf Henkel,Edmund Ko,Ashok Agarwal

Scientific reports 8:14678 PubMed30279523

2018

The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Anja Beckers,Tim Ott,Karin Schuster-Gossler,Karsten Boldt,Leonie Alten,Marius Ueffing,Martin Blum,Achim Gossler

eLife 7: PubMed30084827

2018

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2.

Applications

Unspecified application

Species

Unspecified reactive species

Melissa Kane,Stephanie V Rebensburg,Matthew A Takata,Trinity M Zang,Masahiro Yamashita,Mamuka Kvaratskhelia,Paul D Bieniasz

PloS one 7:e48957 PubMed23152829

2012

Heart failure induces significant changes in nuclear pore complex of human cardiomyocytes.

Applications

WB

Species

Human

Estefanía Tarazón,Miguel Rivera,Esther Roselló-Lletí,Maria Micaela Molina-Navarro,Ignacio José Sánchez-Lázaro,Francisco España,José Anastasio Montero,Francisca Lago,José Ramón González-Juanatey,Manuel Portolés

The Journal of neuroscience : the official journal of the Society for Neuroscience 29:14687-700 PubMed19940164

2009

Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Malte Wittmann,Gillian Queisser,Anja Eder,J Simon Wiegert,C Peter Bengtson,Andrea Hellwig,Gabriel Wittum,Hilmar Bading
View all publications
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