AB176184

Anti-Nurr1 antibody

Name: Anti-Nurr1 antibody (ab176184) | Abcam
Brand: Abcam Limited
SKU: AB176184
Price: 535 USD
Availability: InStock

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(6 Publications)

Rabbit Polyclonal Nurr1 antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human NR4A2 aa 550 to C-terminus.

View Alternative Names

NOT, NURR1, TINUR, NR4A2, Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (AB176184)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (AB176184)

Formalin-fixed, paraffin-embedded mouse kidney tissue stained for Nurr1 using ab176184 at 1 : 50 dilution (IHC Blocking Buffer) in immunohistochemical analysis. Hematoxylin QS (blue) was used to cunterstain.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (AB176184)

Supplier Data

Western blot - Anti-Nurr1 antibody (AB176184)

All lanes:

Western blot - Anti-Nurr1 antibody (ab176184) at 1/500 dilution

Lane 1:

Mouse skeletal muscle tissue lysate

Lane 2:

Mouse heart tissue lysate

Lane 3:

Mouse liver tissue lysate

Lane 4:

Mouse kidney tissue lysate

Lane 5:

Mouse lung tissue lysate

Lane 6:

Mouse large intestine tissue lysate

Lane 7:

Mouse small intestine tissue lysate

Lane 8:

Mouse spleen tissue lysate

Lane 9:

Mouse ovary tissue lysate

Lane 10:

Mouse bladder tissue lysate

Lane 11:

Mouse cerebellum tissue lysate

Lane 12:

Mouse spinal cord tissue lysate

Lane 13:

Mouse brain tissue lysate

Predicted band size: 67 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human NR4A2 aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P43354

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.02% Sodium azide

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Nuclear receptor-related 1 protein (Nurr1) is a transcription factor weighing approximately 66 kDa. Scientists also know Nurr1 as NR4A2 and it belongs to the NR4A nuclear receptor family. Nurr1 is mainly expressed in the central nervous system where it plays a significant role in neuronal development and maintenance. Despite lacking a defined ligand-binding activity Nurr1 regulates gene expression directly by binding to DNA.

Biological function summary

Nurr1 functions as a critical regulator of dopaminergic neurons in the brain. It is vital for the survival and differentiation of these neurons which are important for motor control and behavioral responses. Nurr1 partners with other transcription factors often functioning in complexes that modulate brain-derived neurotrophic factor (BDNF) signaling. It influences the transcription of genes involved in inflammatory responses and neuroprotection reflecting its importance in maintaining neural health.

Pathways

Nurr1 integrates into key biological processes involving dopaminergic signaling and neuroinflammation. Nurr1 directly participates in the Wnt signaling pathway which plays a role in neuronal development and synaptic function. It also interacts with proteins such as Pitx3 and LMX1B within these pathways contributing to the regulation of dopaminergic neuron function and survival ultimately affecting broader central nervous system activity.

Nurr1 has strong associations with neurological conditions such as Parkinson’s disease and schizophrenia. Its impaired function or altered expression can lead to dopaminergic neuron degeneration a hallmark of Parkinson's disease. Research indicates Nurr1's interaction with parkin a protein implicated in the disease's pathology further emphasizes its importance. In schizophrenia altered Nurr1 activity affects synaptic regulation and cognitive function potentially relating to disrupted dopaminergic and BDNF pathways.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed : 15716272, PubMed : 17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).

See full target information NR4A2

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular life sciences : CMLS 82:262 PubMed40580316

2025

NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-κB pathway inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Di Hu,Cheng Huang,Ling Tang,Jiawen Lei,Jiaqi Wang,Wenzheng Hu,Minshan Chen,Siyuan Song,Lin Lu,Pingyi Xu

The Journal of clinical investigation 134: PubMed39403924

2024

Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity.

Applications

Unspecified application

Species

Unspecified reactive species

Ryunosuke Muro,Takeshi Nitta,Sachiko Nitta,Masayuki Tsukasaki,Tatsuo Asano,Kenta Nakano,Tadashi Okamura,Tomoki Nakashima,Kazuo Okamoto,Hiroshi Takayanagi

Environmental toxicology 39:3883-3896 PubMed38563506

2024

Melatonin promotes cell cycle progression of neural stem cells subjected to manganese via Nurr1.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Chen,Han Zhou,Bin He,Sen Peng,Feng Ding,Qi-Hao Liu,Zhuo Ma,Wei Liu,Bin Xu

Cancer discovery 13:974-1001 PubMed36649564

2023

Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Zengpanpan Ye,Xiaolin Ai,Kailin Yang,Zhengnan Yang,Fan Fei,Xiaoling Liao,Zhixin Qiu,Ryan C Gimple,Huairui Yuan,Hao Huang,Yanqiu Gong,Chaoxin Xiao,Jing Yue,Liang Huang,Olivier Saulnier,Wei Wang,Peidong Zhang,Lunzhi Dai,Xin Wang,Xiuxing Wang,Young Ha Ahn,Chao You,Jianguo Xu,Xiaoxiao Wan,Michael D Taylor,Linjie Zhao,Jeremy N Rich,Shengtao Zhou

Journal of neuroinflammation 18:68 PubMed33750404

2021

Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF-κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liuqing Hu,Linjie Si,Xiaonan Dai,Hongquan Dong,Zijian Ma,Zhaochu Sun,Nana Li,Huanhuan Sha,Yinan Chen,Yanning Qian,Zhiyuan Zhang

Frontiers in neuroscience 15:618190 PubMed33679302

2021

The Pathology of Morphine-Inhibited Nerve Repair and Morphine-Induced Nerve Damage Is Mediated via Endoplasmic Reticulum Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Liu,Shanyong Yi,Weibo Shi,Guozhong Zhang,Songjun Wang,Qian Qi,Bin Cong,Yingmin Li

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Nurr1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (AB176184)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (AB176184)

Western blot - Anti-Nurr1 antibody (AB176184)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (6)

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