AB41917

Anti-Nurr1 antibody [N1404]

Name: Anti-Nurr1 antibody [N1404] Mouse monoclonal (ab41917) | Abcam
Brand: Abcam Limited
SKU: AB41917
Price: 350 USD
Availability: InStock
Rating: 4 (9 reviews)

(9 Reviews)

(31 Publications)

Mouse Monoclonal Nurr1 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 31 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NR4A2 aa 1-100.

View Alternative Names

NOT, NURR1, TINUR, NR4A2, Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody [N1404] (AB41917)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody [N1404] (AB41917)

ab41917 staining Nurr1 rat cerebral nerve cell paraffin section (10 ug/mL) by immunohistochemistry, formalin-fixed paraffin embedded sections.

This image was generated using the ascites version of the product.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

N1404

Isotype

IgG2a

Carrier free

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human NR4A2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P43354

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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Product details

This product was changed from ascites to tissue culture supernatant on 3^rd April 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7 Preservative: 0.1% Sodium azide

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Nuclear receptor-related 1 protein (Nurr1) is a transcription factor weighing approximately 66 kDa. Scientists also know Nurr1 as NR4A2 and it belongs to the NR4A nuclear receptor family. Nurr1 is mainly expressed in the central nervous system where it plays a significant role in neuronal development and maintenance. Despite lacking a defined ligand-binding activity Nurr1 regulates gene expression directly by binding to DNA.

Biological function summary

Nurr1 functions as a critical regulator of dopaminergic neurons in the brain. It is vital for the survival and differentiation of these neurons which are important for motor control and behavioral responses. Nurr1 partners with other transcription factors often functioning in complexes that modulate brain-derived neurotrophic factor (BDNF) signaling. It influences the transcription of genes involved in inflammatory responses and neuroprotection reflecting its importance in maintaining neural health.

Pathways

Nurr1 integrates into key biological processes involving dopaminergic signaling and neuroinflammation. Nurr1 directly participates in the Wnt signaling pathway which plays a role in neuronal development and synaptic function. It also interacts with proteins such as Pitx3 and LMX1B within these pathways contributing to the regulation of dopaminergic neuron function and survival ultimately affecting broader central nervous system activity.

Nurr1 has strong associations with neurological conditions such as Parkinson’s disease and schizophrenia. Its impaired function or altered expression can lead to dopaminergic neuron degeneration a hallmark of Parkinson's disease. Research indicates Nurr1's interaction with parkin a protein implicated in the disease's pathology further emphasizes its importance. In schizophrenia altered Nurr1 activity affects synaptic regulation and cognitive function potentially relating to disrupted dopaminergic and BDNF pathways.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed : 15716272, PubMed : 17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).

See full target information NR4A2

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Publications (31)

Recent publications for all applications. Explore the full list and refine your search

Neuroscience bulletin : PubMed40921971

2025

Nr4a2, A Key Factor Controlling the Development and Functional Maintenance of Forebrain Car3 Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Yun-Chao Tao,Li Zhao,Qiong Zhang,Xi-Yue Liu,Wei-Tang Liu,Ze-Xuan Li,Ling Hu,Lei Zhang,Jia-Yin Chen,Yu-Qiang Ding,Ning-Ning Song

Cell death discovery 11:126 PubMed40164579

2025

Satb2 and Nr4a2 are required for the differentiation of cortical layer 6b.

Applications

Unspecified application

Species

Unspecified reactive species

Li Zhao,Yun-Chao Tao,Ling Hu,Xi-Yue Liu,Qiong Zhang,Lei Zhang,Yu-Qiang Ding,Ning-Ning Song

Cell reports methods 4:100845 PubMed39236715

2024

3D model for human glia conversion into subtype-specific neurons, including dopamine neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica Giacomoni,Andreas Bruzelius,Mette Habekost,Janko Kajtez,Daniella Rylander Ottosson,Alessandro Fiorenzano,Petter Storm,Malin Parmar

Molecular neurobiology 60:7222-7237 PubMed37542647

2023

Anti-inflammatory Effects of Siponimod in a Mouse Model of Excitotoxicity-Induced Retinal Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Devaraj Basavarajappa,Vivek Gupta,Nitin Chitranshi,Deepa Viswanathan,Veer Gupta,Roshana Vander Wall,Viswanthram Palanivel,Mehdi Mirzaei,Yuyi You,Alexander Klistorner,Stuart L Graham

Proceedings of the National Academy of Sciences of the United States of America 120:e2220918120 PubMed37406098

2023

Origin and development of the claustrum in rhesus macaque.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Li,Alvaro Duque,Pasko Rakic

Neural regeneration research 18:2037-2046 PubMed36926730

2023

Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect.

Applications

Unspecified application

Species

Unspecified reactive species

Piniel Alphayo Kambey,Wen-Ya Liu,Jiao Wu,Bakwatanisa Bosco,Iqra Nadeem,Kouminin Kanwore,Dian-Shuai Gao

The Journal of neuroscience : the official journal of the Society for Neuroscience 42:4594-4604 PubMed35501151

2022

CREB Inactivation by HDAC1/PP1γ Contributes to Dopaminergic Neurodegeneration in Parkinson's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyi Xu,Xin He,Zeyan Zhang,Yanyi Chen,Junyu Li,Shanshan Ma,Qiaoying Huang,Mingtao Li

Cancer research communications 1:65-78 PubMed35582016

2022

Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Mehrdad Zarei,Rupesh Shrestha,Sneha Johnson,Zuhua Yu,Keshav Karki,Ali Vaziri-Gohar,Jessica Epps,Heng Du,Larry Suva,Mahsa Zarei,Stephen Safe

Oxidative medicine and cellular longevity 2022:4054938 PubMed35140838

2022

BMS-470539 Attenuates Oxidative Stress and Neuronal Apoptosis via MC1R/cAMP/PKA/Nurr1 Signaling Pathway in a Neonatal Hypoxic-Ischemic Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Shufeng Yu,Desislava Met Doycheva,Marcin Gamdzyk,Yuanyuan Gao,Yong Guo,Zackary D Travis,Jiping Tang,Wen-Xiong Chen,John H Zhang

Frontiers in cellular neuroscience 15:803272 PubMed35087379

2022

Synergistic Effects of Combined Nurr1 Overexpression and Natural Inducers on the More Efficient Production of Dopaminergic Neuron-Like Cells From Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Reyhaneh Beiki,Mahsa Khaghani,Fariba Esmaeili,Fariba Dehghanian

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Nurr1 antibody [N1404]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody [N1404] (AB41917)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (31)

Product promise