JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB167039

Anti-NXPH1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal NXPH1 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NXPH1.

View Alternative Names

NPH1, Nbla00697, NXPH1, Neurexophilin-1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NXPH1 antibody (AB167039)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NXPH1 antibody (AB167039)

Imunohistochemical analysis of formalin-fixed, paraffin-embedded Human Adrenal tissue labeling NXPH1 with ab167039 at 5 µg/ml.

Western blot - Anti-NXPH1 antibody (AB167039)
  • WB

Unknown

Western blot - Anti-NXPH1 antibody (AB167039)

All lanes:

Western blot - Anti-NXPH1 antibody (ab167039) at 1/500 dilution

Lane 1:

Rat heart cell extract

Lane 2:

Rat heart cell extract with immunizing peptide

Predicted band size: 31 kDa,57 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human NXPH1. The exact immunogen used to generate this antibody is proprietary information.

P58417

style
left-column

Complementary Products

Primary Antibodies

AB168285

Anti-FAM55A antibody

Western blot - Anti-FAM55A antibody (AB168285)

  • 0
  • 0
Primary Antibodies

AB97436

Anti-RPA14/RPA3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RPA14/RPA3 antibody (AB97436)

  • 0
  • 0
Primary Antibodies

AB139695

Anti-PRKAR1A+PRKAR1B antibody [EPR8491]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRKAR1A+PRKAR1B antibody [EPR8491] (AB139695)

  • 0
  • 0
Primary Antibodies

AB254715

Anti-ZNF503 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF503 antibody (AB254715)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

NXPH1 or Neurexophilin-1 is a protein involved in synaptic function. This protein weighs approximately 32 kDa and plays a role in neurotransmitter release. Researchers recognize NXPH1 by its presence in the central nervous system notably expressed in the brain. NXPH1 acts as a ligand for neurexins which are essential for synapse formation and function.
Biological function summary

Neurexophilin-1 participates in neuronal communication and acts as part of a complex with neurexins. By binding to neurexins NXPH1 influences the organization of synaptic junctions facilitating signaling between neurons. These interactions are critical for processes such as learning and memory as they support the maintenance and regulation of synaptic connections.

Pathways

NXPH1 significantly contributes to the regulation of neurotransmission and synaptic signaling. In the glutamatergic synaptic pathway NXPH1 interacts with neurexins to facilitate the release of glutamate an important neurotransmitter. Additionally it may play a role in the dopaminergic synaptic pathways by influencing dopamine receptor connectivity with proteins like neuroligins.

Neurexophilin-1 has connections to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. In these conditions alterations in NXPH1 expression or function may disrupt synaptic organization leading to impaired neuronal communication. The interaction between NXPH1 and neurexins such as NRXN1 becomes important in understanding the synaptic abnormalities observed in these disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
See full target information NXPH1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Environmental toxicology 37:2398-2411 PubMed35730485

2022

Long noncoding RNA ST8SIA6-AS1 promotes cell proliferation and metastasis in triple-negative breast cancer by targeting miR-145-5p/CDCA3 to inactivate the p53/p21 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Qiao,Bin Wang,Yu Yan,Ligang Niu
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com