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AB168481

Anti-NXT1 antibody

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(1 Publication)

Mouse Polyclonal NXT1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NXT1.

View Alternative Names

NTF2-related export protein 1, Protein p15, NXT1

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-NXT1 antibody (AB168481)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NXT1 antibody (AB168481)

Immunofluorescent analysis of HeLa cells labeling NXT1 with ab168481 at 10 µg/ml.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NXT1.

Q9UKK6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The NXT1 protein also known as NTX1 or nuclear export transporter factor 1 is an essential part of cellular machinery. It has a molecular weight of approximately 17 kDa. Expressed ubiquitously in human tissues NXT1 plays a significant role in nuclear transport processes. The protein forms a critical component of the nuclear export pathway primarily involved in the transport of RNA molecules between the nucleus and the cytoplasm. This function requires a complex interaction with nuclear export signals and other proteins involved in export mechanisms.
Biological function summary

NXT1 acts in coordination with exportin proteins as part of the nuclear export complex. It binds with the nuclear export receptor CRM1 to mediate the transport of RNA and proteins out of the nucleus. This interaction facilitates the shuttling of cargo molecules ensuring proper cellular function and gene expression regulation. By partnering with other export factors NXT1 helps maintain cellular homeostasis and is vital for proper cell cycle progression and signal transduction.

Pathways

Several transport and signaling pathways rely on NXT1's function. It plays a significant role in the nuclear export pathway ensuring the delivery of ribonucleoproteins and mRNA to the cytoplasm for translation. NXT1 interacts closely with other key proteins like CRM1 and RanGTP in this pathway emphasizing its role in cellular traffic control. Furthermore its involvement in the RNA processing pathway links it to broader regulatory networks essential for proper gene expression.

Defects in NXT1 functioning can lead to issues associated with disrupted RNA transport and gene regulation. Abnormalities in its pathway may contribute to the development of conditions like cancer where improper cell cycle regulation is observed. Additionally NXT1 dysfunction is linked to neurodegenerative disorders characterized by misregulated RNA export and protein synthesis. Connections with proteins such as CRM1 highlight the potential for targeted therapeutic approaches in addressing these ailments.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Stimulator of protein export for NES-containing proteins (PubMed : 10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed : 10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed : 11259602, PubMed : 19165146).
See full target information NXT1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Acta biochimica Polonica 69:417-422 PubMed35696596

2022

USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Meiqin Liu,Shile Gao,Xingjun Xu,Lijie Zhang,Bin Xu,Donghui Lu
View all publications
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Product promise

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