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Rabbit Polyclonal OATP1A2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLCO1A2.

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Images

Western blot - Anti-OATP1A2 antibody (AB110392), expandable thumbnail

Publications

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Synthetic Peptide within Human SLCO1A2. The exact immunogen used to generate this antibody is proprietary information. Database link P46721

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested

Tested
Tested

Species
Human
Dilution info
1/500.00000 - 1/1000.00000
Notes

-

Associated Products

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Target data

Function

Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane (PubMed:19129463, PubMed:7557095). Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate) (PubMed:11159893, PubMed:12568656, PubMed:19129463, PubMed:23918469, PubMed:25560245, PubMed:9539145). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision (PubMed:25560245). Involved in the uptake of clinically used drugs (PubMed:17301733, PubMed:20686826, PubMed:27777271). Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (PubMed:19129463, PubMed:20358049). Also transports prostaglandin E2 (PubMed:19129463). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable).

Alternative names

OATP, OATP1, OATP1A2, SLC21A3, SLCO1A2, Solute carrier organic anion transporter family member 1A2, OATP-A, Organic anion-transporting polypeptide 1, Sodium-independent organic anion transporter, Solute carrier family 21 member 3, OATP-1

Recommended products

Rabbit Polyclonal OATP1A2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLCO1A2.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Synthetic Peptide within Human SLCO1A2. The exact immunogen used to generate this antibody is proprietary information. Database link P46721
Purification technique
Affinity purification Immunogen
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

OATP1A2 also known as Organic Anion Transporting Polypeptide 1A2 or SLC21A3 functions as a solute carrier responsible for the transport of various endogenous and exogenous organic anions. This protein plays an important role in drug absorption distribution and clearance. OATP1A2 has a molecular weight of approximately 76 kDa. It is mainly expressed in the liver but you can also find it in the small intestine brain and kidney. Its expression in multiple tissues highlights its significant role in pharmacokinetics.

Biological function summary

OATP1A2 mediates the uptake of a wide range of substrates including bile acids steroid conjugates thyroid hormones and various drugs. It does not form part of a larger protein complex which means it acts independently in its transporter function. The protein facilitates the entry of compounds critical for cellular metabolism and detoxification making it an important player in maintaining cellular homeostasis.

Pathways

This transporter integrates into essential biological processes particularly the hepatic and intestinal transport pathways. In the liver it works in conjunction with other transporters like NTCP and BCRP to manage bile secretion and drug clearance. Moreover it participates in the regulation of drug bioavailability and efficacy often interacting with the P-glycoprotein pathway in the small intestine.

Associated diseases and disorders

OATP1A2 demonstrates an important role in conditions such as cancer and drug-induced toxicity. Alterations in its function or expression can influence cancer development due to impaired drug transport and disposition. Additionally improper functioning of OATP1A2 has been linked to an increased risk of adverse drug reactions particularly in combination with other transporters like NTCP which also share substrates. Understanding these connections helps in managing and predicting treatment outcomes.

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1 product image

  • Western blot - Anti-OATP1A2 antibody (ab110392), expandable thumbnail

    Western blot - Anti-OATP1A2 antibody (ab110392)

    All lanes: Western blot - Anti-OATP1A2 antibody (ab110392) at 1/500 dilution

    Lane 1: extracts from HepG2 cells at 30 µg

    Lane 2: extracts from MCF-7 cells at 30 µg

    Lane 3: extracts from HeLa cells at 30 µg

    Lane 4: extracts from MCF-7 cells at 30 µg with blocking peptide

    Predicted band size: 74 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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