JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB151446

Anti-OB Cadherin antibody [16G5]

Be the first to review this product! Submit a review

|

(5 Publications)

Mouse Monoclonal OB Cadherin antibody. Suitable for WB and reacts with Transfected cell line, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CDH11.

View Alternative Names

Cadherin-11, OSF-4, Osteoblast cadherin, OB-cadherin, CDH11

1 Images
Western blot - Anti-OB Cadherin antibody [16G5] (AB151446)
  • WB

Unknown

Western blot - Anti-OB Cadherin antibody [16G5] (AB151446)

All lanes:

Western blot - Anti-OB Cadherin antibody [16G5] (ab151446) at 1/100 dilution

All lanes:

Scc-1 cells expressing exogenous OB Cadherin

Predicted band size: 87 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

16G5

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human CDH11. The exact immunogen used to generate this antibody is proprietary information.

P55287

style
left-column

Alternative Products

Primary Antibodies

AB151302

Anti-OB Cadherin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OB Cadherin antibody (AB151302)

  • 4
  • 3
Primary Antibodies

AB129760

Anti-OB Cadherin antibody

Western blot - Anti-OB Cadherin antibody (AB129760)

  • 0
  • 0
Primary Antibodies

AB223087

Anti-OB Cadherin antibody

Immunocytochemistry/ Immunofluorescence - Anti-OB Cadherin antibody (AB223087)

  • 5
  • 1

Complementary Products

Assay Kits

AB267594

Human OB Cadherin ELISA Kit

Sandwich ELISA - Human OB Cadherin ELISA Kit (AB267594)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
Primary Antibodies

AB71916

Anti-EpCAM antibody

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-EpCAM antibody (AB71916)

  • 4
  • 20
Primary Antibodies

AB52894

Anti-EGFR antibody [EP38Y]

BOND RX™ Validated|KO Validated|RabMAb|Lab Essentials|20ul selling size|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFR antibody [EP38Y] (AB52894)

  • 5
  • 24
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/100", "WB-species-notes": "<p></p>" }, "Transfected cell line": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OB Cadherin is a calcium-dependent cell adhesion molecule also known as Cadherin-11. It has a mass of about 120 kDa. OB Cadherin is expressed widely in mesenchymal tissues including osteoblasts fibroblasts and synovial tissues. This cadherin plays a role in the regulation of cell-cell adhesion influencing the mechanical structure and integrity of tissues. Its expression in differentiated cells indicates its involvement in tissue maintenance and repair. OB Cadherin is also contributing to the segregation of different cell types during developmental processes.
Biological function summary

OB Cadherin plays an important role in tissue morphogenesis and remodeling. It is a part of the adherens junction complex which also includes catenins. This complex mediates cell contact and communication essential for structural integrity and signaling. OB Cadherin supports the proper organization and separation of cells within tissues impacting processes like bone development and wound healing. It acts as a mediator in mechanical signaling influencing cellular responses to mechanical stress.

Pathways

OB Cadherin participates in signaling pathways involved in cell adhesion and migration notably in the Wnt and BMP pathways. These pathways are essential for developmental processes and maintain tissue homeostasis. OB Cadherin interacts closely with proteins like beta-catenin playing a role in transcriptional regulation that influences cell fate decisions. Its function in these pathways demonstrates its critical role in regulating cellular activities tied to growth and differentiation.

OB Cadherin is linked to conditions like rheumatoid arthritis and cancer metastasis. In rheumatoid arthritis overexpression of OB Cadherin in synovial tissues can contribute to joint inflammation and tissue destruction associated with interactions with fibroblast-like synoviocytes. In cancer metastasis OB Cadherin's role in cell adhesion and migration highlights its potential influence in the spread of cancer cells often in relation to altered interactions with proteins like N-cadherin. These associations make OB Cadherin an important target for research into disease mechanisms and therapies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed : 33811546). Involved in the regulation of cell migration (PubMed : 33811546).
See full target information CDH11
style
left-column

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in neurology 15:1358531 PubMed38481938

2024

Evaluating circulating tumour cell enrichment techniques to establish an appropriate method for clinical application in glioblastomas.

Applications

Unspecified application

Species

Unspecified reactive species

Hannah R Barber,Claire M Perks,Kathreena M Kurian

Nature communications 13:7952 PubMed36572689

2022

Altered sulfation status of FAM20C-dependent chondroitin sulfate is associated with osteosclerotic bone dysplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Toshiyasu Koike,Tadahisa Mikami,Jun-Ichi Tamura,Hiroshi Kitagawa

PloS one 15:e0231276 PubMed32275737

2020

Boron doped silver-copper alloy nanoparticle targeting intracellular S. aureus in bone cells.

Applications

Unspecified application

Species

Unspecified reactive species

Tahir Abdulrehman,Shahnaz Qadri,Sini Skariah,Ali Sultan,Said Mansour,Jamil Azzi,Yousef Haik

Oncology letters 15:9498-9506 PubMed29805672

2018

Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Ma,Ji-Zhi Zhao,Run-Tai Lin,Lian Zhou,Yong-Ning Chen,Li-Jiang Yu,Tian-Yin Shi,Mu Wang,Man-Man Liu,Yao-Ran Liu,Tao Zhang

Bioconjugate chemistry 25:1893-901 PubMed25215471

2014

Universal antibody conjugation to nanoparticles using the Fcγ receptor I (FcγRI): quantitative profiling of membrane biomarkers.

Applications

Unspecified application

Species

Unspecified reactive species

Chloe Kim,Justin F Galloway,Kwan Hyi Lee,Peter C Searson
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com