AB151302

Anti-OB Cadherin antibody

Name: Anti-OB Cadherin antibody (ab151302) | Abcam
Brand: Abcam Limited
SKU: AB151302
Price: 220 USD
Availability: InStock
Rating: 4 (3 reviews)

(3 Reviews)

(14 Publications)

Rabbit Polyclonal OB Cadherin antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 14 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CDH11 aa 50-350.

View Alternative Names

Cadherin-11, OSF-4, Osteoblast cadherin, OB-cadherin, CDH11

1 Images

Supplier Data

Western blot - Anti-OB Cadherin antibody (AB151302)

Samples were separated by 5% SDS-PAGE.

All lanes:

Western blot - Anti-OB Cadherin antibody (ab151302) at 1/500 dilution

Lane 1:

PC-3 whole cell lysates at 50 µg

Lane 2:

MCF-7 whole cell lysates at 50 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 120 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human CDH11 aa 50-350. The exact immunogen used to generate this antibody is proprietary information.

P55287

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OB Cadherin is a calcium-dependent cell adhesion molecule also known as Cadherin-11. It has a mass of about 120 kDa. OB Cadherin is expressed widely in mesenchymal tissues including osteoblasts fibroblasts and synovial tissues. This cadherin plays a role in the regulation of cell-cell adhesion influencing the mechanical structure and integrity of tissues. Its expression in differentiated cells indicates its involvement in tissue maintenance and repair. OB Cadherin is also contributing to the segregation of different cell types during developmental processes.

Biological function summary

OB Cadherin plays an important role in tissue morphogenesis and remodeling. It is a part of the adherens junction complex which also includes catenins. This complex mediates cell contact and communication essential for structural integrity and signaling. OB Cadherin supports the proper organization and separation of cells within tissues impacting processes like bone development and wound healing. It acts as a mediator in mechanical signaling influencing cellular responses to mechanical stress.

Pathways

OB Cadherin participates in signaling pathways involved in cell adhesion and migration notably in the Wnt and BMP pathways. These pathways are essential for developmental processes and maintain tissue homeostasis. OB Cadherin interacts closely with proteins like beta-catenin playing a role in transcriptional regulation that influences cell fate decisions. Its function in these pathways demonstrates its critical role in regulating cellular activities tied to growth and differentiation.

OB Cadherin is linked to conditions like rheumatoid arthritis and cancer metastasis. In rheumatoid arthritis overexpression of OB Cadherin in synovial tissues can contribute to joint inflammation and tissue destruction associated with interactions with fibroblast-like synoviocytes. In cancer metastasis OB Cadherin's role in cell adhesion and migration highlights its potential influence in the spread of cancer cells often in relation to altered interactions with proteins like N-cadherin. These associations make OB Cadherin an important target for research into disease mechanisms and therapies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed : 33811546). Involved in the regulation of cell migration (PubMed : 33811546).

See full target information CDH11

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 9: PubMed38227377

2024

C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Zhang,Sofia Bin,Kelly Budge,Astgik Petrosyan,Valentina Villani,Paola Aguiari,Coralien Vink,Jack Wetzels,Hasmik Soloyan,Gaetano La Manna,Manuel Alfredo Podestà,Paolo Molinari,Sargis Sedrakyan,Kevin V Lemley,Roger E De Filippo,Laura Perin,Paolo Cravedi,Stefano Da Sacco

Journal of tissue engineering and regenerative medicine 2023:9985334 PubMed40226415

2023

Effect of Cadherin-11 on the Proliferation, Migration, and ECM Synthesis of Chondrocyte.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Li,Hang Shi,Xia Liu,Haiyue Jiang

Pediatric investigation 6:100-110 PubMed35774522

2022

Upregulation of cadherin-11 contributes to cholestatic liver fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Wu,Xinbei Tian,Weipeng Wang,Jing Zhu,Ying Lu,Jun Du,Yongtao Xiao

Journal of tissue engineering and regenerative medicine 16:188-199 PubMed34837334

2021

Cadherin-11 promotes the mechanical strength of engineered elastic cartilage by enhancing extracellular matrix synthesis and microstructure.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Li,Rui Cao,Qian Wang,Hang Shi,Yi Wu,Kexin Sun,Xia Liu,Haiyue Jiang

Molecular and cellular biochemistry 476:3353-3363 PubMed33942219

2021

Biomarkers and heterogeneous fibroblast phenotype associated with incisional hernia.

Applications

Unspecified application

Species

Unspecified reactive species

Finosh G Thankam,Nicholas K Larsen,Ann Varghese,Thao-Nguyen Bui,Matthew Reilly,Robert J Fitzgibbons,Devendra K Agrawal

Aging 13:10275-10288 PubMed33819188

2021

CircRNA hsa_circ_0006215 promotes osteogenic differentiation of BMSCs and enhances osteogenesis-angiogenesis coupling by competitively binding to miR-942-5p and regulating RUNX2 and VEGF.

Applications

Unspecified application

Species

Unspecified reactive species

Houlin Ji,Xu Cui,Yang Yang,Xiaoxiao Zhou

Cell death & disease 11:486 PubMed32587236

2020

LncRNA ENST00000563492 promoting the osteogenesis-angiogenesis coupling process in bone mesenchymal stem cells (BMSCs) by functions as a ceRNA for miR-205-5p.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengxiao Ouyang,Tingting Tan,Xianghong Zhang,Jia Wan,Yanling Zhou,Guangyao Jiang,Daishui Yang,Tang Liu

Japanese journal of clinical oncology 50:456-464 PubMed31894237

2020

Predictive value of cadherin-11 for subsequent recurrence and progression in non-muscle invasive bladder cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Kun Chen,Zi-Jian Chen,Kang-Hua Xiao,Zi-Ke Qin,Yun-Lin Ye,Wei-Jie Wen,Jun Bian,Kang-Yi Xue,Qi-Zhao Zhou,Wen-Bing Guo,Jun-Hao Zhou,Ming Xia,Xin Li,Cun-Dong Liu

American journal of cancer research 9:2618-2633 PubMed31911850

2019

DcR3 promotes proliferation and invasion of pancreatic cancer via a DcR3/STAT1/IRF1 feedback loop.

Applications

Unspecified application

Species

Unspecified reactive species

Yijun Wei,Xingyu Chen,Jian Yang,Jun Yao,Ni Yin,Zixiang Zhang,Dechun Li,Dongming Zhu,Jian Zhou

Scientific reports 9:6374 PubMed31011190

2019

Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yo Ueda,Jun Saegusa,Takaichi Okano,Sho Sendo,Hirotaka Yamada,Keisuke Nishimura,Akio Morinobu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-OB Cadherin antibody

Western blot - Anti-OB Cadherin antibody (AB151302)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (14)

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