Rabbit Polyclonal OBSL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Obscurin-like protein 1.
IgG
Rabbit
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/5000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/20.00000 - 1/200.00000 | Notes - |
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Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons.
KIAA0657, KIAA0657, OBSL1, Obscurin-like protein 1
Rabbit Polyclonal OBSL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Obscurin-like protein 1.
IgG
Rabbit
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Affinity purification Protein G
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
The target OBSL1 also known as Obscurin-like 1 is a protein mechanically involved in the cellular architecture. It possesses a mass of approximately 189 kDa. OBSL1 is known for its expression in various tissues notably in muscle and heart. It helps maintain structural integrity by interacting with cytoskeletal proteins. This protein features multiple domains that enable its structural functions and protein-protein interactions.
The role of Obscurin-like 1 extends to maintaining cytoskeletal stability. It is involved in muscle and skeletal systems contributing to the organization of myofibrils. OBSL1 functions as part of a protein complex that helps connect the contractile apparatus to the sarcolemma. It interacts extensively with other cytoskeletal elements coordinating the proper alignment and spacing of muscle fibers which is important for muscle function.
The interactions involving Obscurin-like 1 pertain to the signaling mechanisms that regulate muscle development and repair. The protein participates in pathways such as the integrin signaling pathway and the regulation of the cytoskeleton. It shows association with proteins like titin and ankyrin playing a critical role in the assembly and maintenance of muscle cells. These interactions facilitate cellular response to mechanical stress and help organize sarcomeres.
Research links Obscurin-like 1 with muscular disorders and growth deficiencies. Mutations or dysregulation in OBSL1 have connections to conditions like 3M syndrome which affects growth hormone signaling pathways and results in growth retardation. The protein associates with CUL7 which is involved in ubiquitination processes. Alterations in OBSL1 can disrupt normal cellular function highlighting its importance in health and disease.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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All lanes: Western blot - Anti-OBSL1 antibody (ab224588) at 1/500 dilution
Lane 1: HepG2 (human liver hepatocellular carcinoma cell line) cell lysate
Lane 2: MCF7 (human breast adenocarcinoma cell line) cell lysate
Lane 3: A549 (human lung carcinoma cell line) cell lysate
All lanes: Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 207 kDa, 51 kDa
Observed band size: 207 kDa
Paraffin-embedded human placenta tissue stained for OBSL1 using ab224588 at 1/100 dilution in immunohistochemical analysis.
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