AB221052

Anti-OC-3 antibody

Name: Anti-OC-3 antibody (ab221052) | Abcam
Brand: Abcam Limited
SKU: AB221052
Price: 645 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal OC-3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ONECUT3 aa 150-250.

View Alternative Names

One cut domain family member 3, One cut homeobox 3, Transcription factor ONECUT-3, OC-3, ONECUT3

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-OC-3 antibody (AB221052)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-OC-3 antibody (AB221052)

Immunofluorescent analysis of PFA-fixed/Triton X-100 permeabilized PC3 cells labeling OC-3 with ab221052 at 4 μg/ml (green).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ONECUT3 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

O60422

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The OC-3 protein often referred to in literature as “ocean calcium-3” encapsulates a set of isoforms characterized by significant molecular roles. This protein is estimated to have a mass ranging roughly from 50 to 60 kDa. OC-3 is prominently expressed in several tissues including the nervous system and epithelial tissues. Its mechanical action involves modulation of intracellular calcium levels further influencing various signal transduction processes.

Biological function summary

OC-3 contributes to cellular homeostasis especially in calcium ion management which is essential for maintaining cellular functions. It forms part of larger protein complexes that actively regulate calcium influx and efflux. These complexes ensure controlled calcium signaling within cells which is important for activation and deactivation of cellular responses. As a member of this complex OC-3 interacts dynamically with ion channels across cell membranes.

Pathways

The role of the OC-3 protein manifests significantly in calcium signaling pathways and muscle contraction pathways. These pathways involve interactions with various proteins such as calmodulin and phospholamban which mediate vital functions including muscle relaxation and contraction. OC-3’s influence in these pathways highlights its role in facilitating precise biological outcomes through regulated calcium metabolism.

Altered OC-3 expression or dysfunction can directly impact cardiovascular systems leading to conditions such as hypertension. The protein also shares associations with neurodegenerative disorders impacting neurotransmitter release and neuronal excitability. In these contexts OC-3’s interactions with key proteins like ryanodine receptors can exacerbate or mitigate disease progression depending on the regulatory environment within cells.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).

See full target information ONECUT3

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cell science 135: PubMed34897463

2022

Comparative analysis of vertebrates reveals that mouse primordial oocytes do not contain a Balbiani body.

Applications

Unspecified application

Species

Unspecified reactive species

Laasya Dhandapani,Marion C Salzer,Juan M Duran,Gabriele Zaffagnini,Cristian De Guirior,Maria Angeles Martínez-Zamora,Elvan Böke

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-OC-3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-OC-3 antibody (AB221052)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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