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AB91574

Anti-OCIAD1 antibody

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(2 Publications)

Rabbit Polyclonal OCIAD1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human OCIAD1.

View Alternative Names

ASRIJ, OCIA, OCIAD1, OCIA domain-containing protein 1, Ovarian cancer immunoreactive antigen domain containing 1, Ovarian carcinoma immunoreactive antigen

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-OCIAD1 antibody (AB91574)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-OCIAD1 antibody (AB91574)

Immunofluorescence of OCIAD1 in 293 cells with ab91574 at 20 ug/mL.

Western blot - Anti-OCIAD1 antibody (AB91574)
  • WB

Unknown

Western blot - Anti-OCIAD1 antibody (AB91574)

Lane 1:

Western blot - Anti-OCIAD1 antibody (ab91574) at 1 µg/mL

Lane 2:

Western blot - Anti-OCIAD1 antibody (ab91574) at 2 µg/mL

All lanes:

293 cell lysate at 15 µg

Predicted band size: 28 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human OCIAD1. The exact immunogen used to generate this antibody is proprietary information.

Q9NX40

Specificity

This antibody will not crossreact with OCIAD2.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OCIAD1 also known as ovary carcinoma-associated disintegrin-domain containing protein 1 is a protein with a mass of approximately 35 kDa. It is expressed in various tissues with high levels observed in the ovaries and the central nervous system. Structurally OCIAD1 contains domains that may influence cellular interactions and signal transduction. Studies suggest that OCIAD1 influences cellular processes by participating in membrane-associated complexes which could be important for its mechanical roles.
Biological function summary

OCIAD1 engages in cellular signaling and regulation. It might be a part of a protein complex that contributes to cellular adhesion and proliferation. OCIAD1 appears to support cellular growth and may steer certain cell developmental pathways. By interacting with other proteins it could modulate cellular response mechanisms suggesting its importance in maintaining normal cellular function.

Pathways

OCIAD1 plays roles that impact the PI3K/AKT signaling pathway and the MAPK/ERK pathway. These pathways are essential for the regulation of cell survival growth and differentiation. Within these networks OCIAD1 may interact with proteins like AKT1 and ERK2 facilitating signal transduction that drives cellular responses. Its involvement in these pathways indicates a role in the modulation of critical intracellular signaling events.

OCIAD1 has an established link with ovarian cancer and neurodegenerative diseases such as Alzheimer's disease. In ovarian cancer OCIAD1 might contribute to the malignant transformation and tumor progression possibly in connection with proteins such as p53. In Alzheimer's disease altered OCIAD1 expression could affect proteins like tau which plays a significant role in neurofibrillary tangles. These associations suggest OCIAD1 as a potential target for therapeutic interventions in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed : 20515946).
See full target information OCIAD1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroinflammation 22:89 PubMed40114191

2025

Asrij/OCIAD1 depletion reduces inflammatory microglial activation and ameliorates Aβ pathology in an Alzheimer's disease mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Prathamesh Dongre,Madhu Ramesh,Thimmaiah Govindaraju,Maneesha S Inamdar

Scientific reports 8:7362 PubMed29743632

2018

A double helical motif in OCIAD2 is essential for its localization, interactions and STAT3 activation.

Applications

Unspecified application

Species

Unspecified reactive species

Saloni Sinha,Venkata Anudeep Bheemsetty,Maneesha S Inamdar
View all publications
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Product promise

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