Rabbit Polyclonal OCIAD1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OCIAD1.
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Publications
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- Scientific reports 8:73622018A double helical motif in OCIAD2 is essential for its localization, interactions and STAT3 activation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSaloni Sinha et. al.PubMed 29743632
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human OCIAD1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NX40
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1.00000-2.00000 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 20 µg/mL | Notes - |
Target data
Function
Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946).
Alternative names
ASRIJ, OCIA, OCIAD1, OCIA domain-containing protein 1, Ovarian cancer immunoreactive antigen domain containing 1, Ovarian carcinoma immunoreactive antigen
Recommended products
Rabbit Polyclonal OCIAD1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OCIAD1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human OCIAD1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NX40
- Purification technique
- Affinity purification Immunogen
- Specificity
This antibody will not crossreact with OCIAD2.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
OCIAD1 also known as ovary carcinoma-associated disintegrin-domain containing protein 1 is a protein with a mass of approximately 35 kDa. It is expressed in various tissues with high levels observed in the ovaries and the central nervous system. Structurally OCIAD1 contains domains that may influence cellular interactions and signal transduction. Studies suggest that OCIAD1 influences cellular processes by participating in membrane-associated complexes which could be important for its mechanical roles.
- Biological function summary
OCIAD1 engages in cellular signaling and regulation. It might be a part of a protein complex that contributes to cellular adhesion and proliferation. OCIAD1 appears to support cellular growth and may steer certain cell developmental pathways. By interacting with other proteins it could modulate cellular response mechanisms suggesting its importance in maintaining normal cellular function.
- Pathways
OCIAD1 plays roles that impact the PI3K/AKT signaling pathway and the MAPK/ERK pathway. These pathways are essential for the regulation of cell survival growth and differentiation. Within these networks OCIAD1 may interact with proteins like AKT1 and ERK2 facilitating signal transduction that drives cellular responses. Its involvement in these pathways indicates a role in the modulation of critical intracellular signaling events.
- Associated diseases and disorders
OCIAD1 has an established link with ovarian cancer and neurodegenerative diseases such as Alzheimer's disease. In ovarian cancer OCIAD1 might contribute to the malignant transformation and tumor progression possibly in connection with proteins such as p53. In Alzheimer's disease altered OCIAD1 expression could affect proteins like tau which plays a significant role in neurofibrillary tangles. These associations suggest OCIAD1 as a potential target for therapeutic interventions in these conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunocytochemistry/ Immunofluorescence - Anti-OCIAD1 antibody (ab91574)
Immunofluorescence of OCIAD1 in 293 cells with ab91574 at 20 ug/mL.
Western blot - Anti-OCIAD1 antibody (ab91574)
Lane 1: Western blot - Anti-OCIAD1 antibody (ab91574) at 1 µg/mL
Lane 2: Western blot - Anti-OCIAD1 antibody (ab91574) at 2 µg/mL
All lanes: 293 cell lysate at 15 µg
Predicted band size: 28 kDa
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