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AB110647

Anti-OCM2 antibody [EPR5310]

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(1 Publication)

Rabbit Recombinant Monoclonal OCM2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.

View Alternative Names

OCMN, OCM2, Oncomodulin-2

2 Images
Western blot - Anti-OCM2 antibody [EPR5310] (AB110647)
  • WB

Unknown

Western blot - Anti-OCM2 antibody [EPR5310] (AB110647)

All lanes:

Western blot - Anti-OCM2 antibody [EPR5310] (ab110647) at 1/1000 dilution

Lane 1:

Human placenta lysate at 10 µg

Lane 2:

Mouse heart lysate at 10 µg

Lane 3:

Rat heart lysate at 10 µg

Lane 4:

Fetal heart lysate at 10 µg

Lane 5:

Mouse kidney lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 12 kDa

Observed band size: 12 kDa

false

OI-RD Scanning - Anti-OCM2 antibody [EPR5310] (AB110647)
  • OI-RD Scanning

Unknown

OI-RD Scanning - Anti-OCM2 antibody [EPR5310] (AB110647)

We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody. Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

  • Carrier free

    Anti-OCM2 antibody [EPR5310] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR5310

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OCM2 also known as Oncomodulin 2 is a calcium-binding protein with a molecular mass of approximately 12 kDa. It belongs to the family of EF-hand proteins and is part of the wider calmodulin group. OCM2 shows expression mainly in the retina and cochlea indicating its role in sensory functions. This protein is essential for calcium ion homeostasis requiring accurate localization to exert its functions in physiological conditions.
Biological function summary

Oncomodulin 2 plays a role in regulating intracellular calcium levels which affects various cellular processes. It does not appear to function as part of a known complex. Its expression in sensory areas like the retina and cochlea suggests involvement in signal transduction pathways related to visual and auditory functions. By modulating calcium ions OCM2 supports neuronal specificity and survival indicating a potential role in the development and maintenance of sensory tissues.

Pathways

OCM2 contributes to calcium signaling pathways that are important for cellular communication and regulation. It interacts with proteins such as calmodulin and troponin C which are integral to calcium signal transduction. These pathways relay messages important for cellular adaptation to environmental changes and for the maintenance of cellular homeostasis. The protein's ability to bind calcium supports mechanistic activities within these pathways.

Variations or dysfunction of OCM2 associate with sensory impairments such as retinal degeneration and certain forms of hearing loss. Studies indicate a connection to proteins like Nrl and Myo7a within these conditions. Such associations highlight the potential for OCM2 as a biomarker or therapeutic target in treating sensory-related disorders. The disease links reinforce the understanding of OCM2’s role in sensory organ function and pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information OCM2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature 506:445-50 PubMed24553142

2014

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.

Applications

Unspecified application

Species

Unspecified reactive species

S C Mack,H Witt,R M Piro,L Gu,S Zuyderduyn,A M Stütz,X Wang,M Gallo,L Garzia,K Zayne,X Zhang,V Ramaswamy,N Jäger,D T W Jones,M Sill,T J Pugh,M Ryzhova,K M Wani,D J H Shih,R Head,M Remke,S D Bailey,T Zichner,C C Faria,M Barszczyk,S Stark,H Seker-Cin,S Hutter,P Johann,S Bender,V Hovestadt,T Tzaridis,A M Dubuc,P A Northcott,J Peacock,K C Bertrand,S Agnihotri,F M G Cavalli,I Clarke,K Nethery-Brokx,C L Creasy,S K Verma,J Koster,X Wu,Y Yao,T Milde,P Sin-Chan,J Zuccaro,L Lau,S Pereira,P Castelo-Branco,M Hirst,M A Marra,S S Roberts,D Fults,L Massimi,Y J Cho,T Van Meter,W Grajkowska,B Lach,A E Kulozik,A von Deimling,O Witt,S W Scherer,X Fan,K M Muraszko,M Kool,S L Pomeroy,N Gupta,J Phillips,A Huang,U Tabori,C Hawkins,D Malkin,P N Kongkham,W A Weiss,N Jabado,J T Rutka,E Bouffet,J O Korbel,M Lupien,K D Aldape,G D Bader,R Eils,P Lichter,P B Dirks,S M Pfister,A Korshunov,M D Taylor
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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