Rabbit Recombinant Monoclonal OCM2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples.
Images
![Western blot - Anti-OCM2 antibody [EPR5310] (AB110647), expandable thumbnail](https://content.abcam.com/products/images/ocm2-antibody-epr5310-ab110647--western-blot-img116085.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-OCM2 antibody [EPR5310] (AB110647)")
![OI-RD Scanning - Anti-OCM2 antibody [EPR5310] (AB110647), expandable thumbnail](https://content.abcam.com/products/images/ocm2-antibody-epr5310-ab110647--oi-rd-scanning-img85018.jpg/_jcr_content/renditions/webp-475.webp "OI-RD Scanning - Anti-OCM2 antibody [EPR5310] (AB110647)")
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| ICC/IF | IP | WB | IHC-P | |
|---|---|---|---|---|
| Human | Not recommended | Not recommended | Tested | Not recommended |
| Mouse | Not recommended | Not recommended | Tested | Not recommended |
| Rat | Not recommended | Not recommended | Tested | Not recommended |
ICC/IF
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info - | Notes - |
IP
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000 - 1/10000 | Notes - |
Species Mouse | Dilution info 1/1000 - 1/10000 | Notes - |
Species Rat | Dilution info 1/1000 - 1/10000 | Notes - |
IHC-P
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Human | Dilution info - | Notes - |
Target data
Alternative names
OCMN, OCM2, Putative oncomodulin-2
Recommended products
Rabbit Recombinant Monoclonal OCM2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- EPR5310
- Purification technique
- Affinity purification Protein A
- Dissociation constant
- 1.2 x 10-12 M
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
OCM2 also known as Oncomodulin 2 is a calcium-binding protein with a molecular mass of approximately 12 kDa. It belongs to the family of EF-hand proteins and is part of the wider calmodulin group. OCM2 shows expression mainly in the retina and cochlea indicating its role in sensory functions. This protein is essential for calcium ion homeostasis requiring accurate localization to exert its functions in physiological conditions.
- Biological function summary
Oncomodulin 2 plays a role in regulating intracellular calcium levels which affects various cellular processes. It does not appear to function as part of a known complex. Its expression in sensory areas like the retina and cochlea suggests involvement in signal transduction pathways related to visual and auditory functions. By modulating calcium ions OCM2 supports neuronal specificity and survival indicating a potential role in the development and maintenance of sensory tissues.
- Pathways
OCM2 contributes to calcium signaling pathways that are important for cellular communication and regulation. It interacts with proteins such as calmodulin and troponin C which are integral to calcium signal transduction. These pathways relay messages important for cellular adaptation to environmental changes and for the maintenance of cellular homeostasis. The protein's ability to bind calcium supports mechanistic activities within these pathways.
- Associated diseases and disorders
Variations or dysfunction of OCM2 associate with sensory impairments such as retinal degeneration and certain forms of hearing loss. Studies indicate a connection to proteins like Nrl and Myo7a within these conditions. Such associations highlight the potential for OCM2 as a biomarker or therapeutic target in treating sensory-related disorders. The disease links reinforce the understanding of OCM2’s role in sensory organ function and pathogenesis.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
![Western blot - Anti-OCM2 antibody [EPR5310] (ab110647), expandable thumbnail](https://content.abcam.com/products/images/ocm2-antibody-epr5310-ab110647--western-blot-img116085.jpg "Western blot - Anti-OCM2 antibody [EPR5310] (ab110647)")
Western blot - Anti-OCM2 antibody [EPR5310] (ab110647)
All lanes: Western blot - Anti-OCM2 antibody [EPR5310] (ab110647) at 1/1000 dilution
Lane 1: Human placenta lysate at 10 µg
Lane 2: Mouse heart lysate at 10 µg
Lane 3: Rat heart lysate at 10 µg
Lane 4: Fetal heart lysate at 10 µg
Lane 5: Mouse kidney lysate at 10 µg
SecondaryAll lanes: HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 12 kDa
Observed band size: 12 kDa
![OI-RD Scanning - Anti-OCM2 antibody [EPR5310] (ab110647), expandable thumbnail](https://content.abcam.com/products/images/ocm2-antibody-epr5310-ab110647--oi-rd-scanning-img85018.jpg "OI-RD Scanning - Anti-OCM2 antibody [EPR5310] (ab110647)")
OI-RD Scanning - Anti-OCM2 antibody [EPR5310] (ab110647)
We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody.
Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com