Skip to main content

Rabbit Recombinant Monoclonal OCM2 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples.

Be the first to review this product! Submit a review

Images

Western blot - Anti-OCM2 antibody [EPR5310] - BSA and Azide free (AB247929), expandable thumbnail
  • OI-RD Scanning - Anti-OCM2 antibody [EPR5310] - BSA and Azide free (AB247929), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2 - 7.4
Constituents: PBS

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
ICC/IFIPWBIHC-P
Human
Not recommended
Not recommended
Tested
Not recommended
Mouse
Not recommended
Not recommended
Tested
Not recommended
Rat
Not recommended
Not recommended
Tested
Not recommended

Not recommended
Not recommended

Species
Mouse, Rat, Human
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Mouse, Rat, Human
Dilution info
-
Notes

-

Tested
Tested

Species
Human, Mouse, Rat
Dilution info
-
Notes

-

Not recommended
Not recommended

Species
Mouse, Rat, Human
Dilution info
-
Notes

-

Target data

Alternative names

OCMN, OCM2, Putative oncomodulin-2

Recommended products

Rabbit Recombinant Monoclonal OCM2 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Carrier free
Yes
Clone number
EPR5310
Purification technique
Affinity purification Protein A
Dissociation constant
1.2 x 10-12 M
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Do Not Freeze

Notes

ab247929 is the carrier-free version of Anti-OCM2 antibody [EPR5310] ab110647.

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.

This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

OCM2 also known as Oncomodulin 2 is a calcium-binding protein with a molecular mass of approximately 12 kDa. It belongs to the family of EF-hand proteins and is part of the wider calmodulin group. OCM2 shows expression mainly in the retina and cochlea indicating its role in sensory functions. This protein is essential for calcium ion homeostasis requiring accurate localization to exert its functions in physiological conditions.

Biological function summary

Oncomodulin 2 plays a role in regulating intracellular calcium levels which affects various cellular processes. It does not appear to function as part of a known complex. Its expression in sensory areas like the retina and cochlea suggests involvement in signal transduction pathways related to visual and auditory functions. By modulating calcium ions OCM2 supports neuronal specificity and survival indicating a potential role in the development and maintenance of sensory tissues.

Pathways

OCM2 contributes to calcium signaling pathways that are important for cellular communication and regulation. It interacts with proteins such as calmodulin and troponin C which are integral to calcium signal transduction. These pathways relay messages important for cellular adaptation to environmental changes and for the maintenance of cellular homeostasis. The protein's ability to bind calcium supports mechanistic activities within these pathways.

Associated diseases and disorders

Variations or dysfunction of OCM2 associate with sensory impairments such as retinal degeneration and certain forms of hearing loss. Studies indicate a connection to proteins like Nrl and Myo7a within these conditions. Such associations highlight the potential for OCM2 as a biomarker or therapeutic target in treating sensory-related disorders. The disease links reinforce the understanding of OCM2’s role in sensory organ function and pathogenesis.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Western blot - Anti-OCM2 antibody [EPR5310] - BSA and Azide free (ab247929), expandable thumbnail

    Western blot - Anti-OCM2 antibody [EPR5310] - BSA and Azide free (ab247929)

    This data was developed using Anti-OCM2 antibody [EPR5310] ab110647, the same antibody clone in a different buffer formulation.

    All lanes: Western blot - Anti-OCM2 antibody [EPR5310] (Anti-OCM2 antibody [EPR5310] ab110647) at 1/1000 dilution

    Lane 1: Human placenta lysate at 10 µg

    Lane 2: Mouse heart lysate at 10 µg

    Lane 3: Rat heart lysate at 10 µg

    Lane 4: Fetal heart lysate at 10 µg

    Lane 5: Mouse kidney lysate at 10 µg

    Secondary

    All lanes: HRP labelled goat anti-rabbit at 1/2000 dilution

    Predicted band size: 12 kDa

    Observed band size: 12 kDa

  • OI-RD Scanning - Anti-OCM2 antibody [EPR5310] - BSA and Azide free (ab247929), expandable thumbnail

    OI-RD Scanning - Anti-OCM2 antibody [EPR5310] - BSA and Azide free (ab247929)

    We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody.
    Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com