Anti-ODF1 antibody [EPR15496]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

ODF1 also known as Outer Dense Fiber Protein 1 plays an important role in the structural integrity of sperm flagella. The protein has a molecular mass of approximately 29 kDa. It localizes particularly to the outer dense fibers of sperm cells an important site for motility. Expression of ODF1 occurs primarily in the testis especially in mature spermatozoa where it contributes to the stability and function of the sperm tail.

Biological function summary

ODF1 contributes significantly to sperm motility and structural support within the sperm flagellum. As part of more complex structures ODF1 interacts with other potential flagellar components to ensure adequate mechanical support during sperm movement. By providing this stability ODF1 enables sperm cells to withstand the mechanical forces they encounter in the reproductive tract which is essential for male fertility.

Pathways

Several critical molecular interactions link ODF1 to reproductive success and sperm motility. Notably it plays a role within the sperm motility pathway and is interconnected with other structural proteins such as AKAP3 (A-Kinase Anchoring Protein 3) to provide anchoring points and scaffolding within the sperm tail. These pathways maintain proper structural function which is important for efficient motility and fertility.

Associated diseases and disorders

Dysfunction or mutations in ODF1 may lead to male fertility issues such as asthenozoospermia characterized by reduced sperm motility. Research suggests a potential interaction with related proteins such as SPAG16 (Sperm Associated Antigen 16) which may further influence motility and structural integrity. Understanding these relationships can help in creating targeted therapies and diagnostics for reproductive health.