AB233214

Anti-Ogg1 antibody

Name: Anti-Ogg1 antibody (ab233214) | Abcam
Brand: Abcam Limited
SKU: AB233214
Price: 525 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal OGG1 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OGG1 aa 1 to C-terminus.

View Alternative Names

MMH, MUTM, OGH1, OGG1, N-glycosylase/DNA lyase

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ogg1 antibody (AB233214)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ogg1 antibody (AB233214)

Formalin-fixed, paraffin-embedded human brain tissue stained for Ogg1 using ab233214 at 20 μg/mL in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ogg1 antibody (AB233214)

Formalin-fixed, paraffin-embedded human liver tissue stained for Ogg1 using ab233214 at 30 μg/mL in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-Ogg1 antibody (AB233214)

All lanes:

Western blot - Anti-Ogg1 antibody (ab233214) at 2 µg/mL

All lanes:

Recombinant human Ogg1 protein

Predicted band size: 39 kDa

false

Supplier Data

Western blot - Anti-Ogg1 antibody (AB233214)

All lanes:

Western blot - Anti-Ogg1 antibody (ab233214) at 2 µg/mL

Lane 1:

Pig heart lysate

Lane 2:

Pig kidney lysate

Secondary

All lanes:

HRP-Linked Guinea pig anti-rabbit at 1/1000 dilution

Predicted band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human OGG1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O15527

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Ogg1 protein also known as 8-oxoguanine DNA glycosylase or Oggone is an important repair enzyme responsible for the removal of oxidatively damaged guanine bases from DNA. This protein has a molecular mass of approximately 39 kDa and is expressed in various tissues including the brain liver and lungs. Ogg1 is significant in maintaining genome integrity by excising 8-oxoguanine lesions which can otherwise lead to mutations if left unrepaired.

Biological function summary

Within cellular processes Ogg1 functions primarily to maintain DNA stability by participating in the base excision repair pathway. This protein operates as part of a complex that identifies and excises damaged bases subsequently facilitating the refilling and ligation of the resulting single-strand DNA breaks. The removal of oxidized guanine by Ogg1 is important in preventing mutagenesis apoptosis and tumorigenesis.

Pathways

The involvement of Ogg1 can be predominantly seen in the DNA repair and oxidative stress response pathways. Within these pathways Ogg1 is closely related to other proteins such as MutYH and APE1 which work collaboratively to ensure DNA integrity. Coordinating with other repair enzymes Ogg1 therefore helps to counteract the effects of reactive oxygen species-induced damage on the genetic material.

Studies link abnormal Ogg1 activity to increased risk for cancer and neurodegenerative diseases. Mutations or deficiencies in the Ogg1 protein can result in an accumulation of 8-oxoguanine promoting genomic instability and potentially facilitating cancer development. Additionally the accumulation of oxidative DNA damage is associated with Alzheimer's disease where Ogg1 interaction with proteins like APE1 can influence disease progression by affecting the efficiency of DNA repair mechanisms.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

See full target information OGG1

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nutrition & metabolism 22:109 PubMed41029463

2025

mTOR-autophagy axis regulation by intermittent fasting promotes skeletal muscle growth and differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Xinyan,Wu Yajie,He Shangfan,Yang Yuefei,Li Junwei,Zhu Jiaqiao,Ju Huiming

EMBO molecular medicine 16:2322-2348 PubMed39300235

2024

Liver protects neuron viability and electrocortical activity in post-cardiac arrest brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiyong Guo,Meixian Yin,Chengjun Sun,Guixing Xu,Tielong Wang,Zehua Jia,Zhiheng Zhang,Caihui Zhu,Donghua Zheng,Linhe Wang,Shanzhou Huang,Di Liu,Yixi Zhang,Rongxing Xie,Ningxin Gao,Liqiang Zhan,Shujiao He,Yifan Zhu,Yuexin Li,Björn Nashan,Schlegel Andrea,Jin Xu,Qiang Zhao,Xiaoshun He

Nucleic acids research 52:5107-5120 PubMed38554113

2024

SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Anke Geng,Jiahui Sun,Huanyin Tang,Yang Yu,Xiyue Wang,Jingyuan Zhang,Xiaona Wang,Xiaoxiang Sun,Xiaofang Zhou,Neng Gao,Rong Tan,Zhu Xu,Ying Jiang,Zhiyong Mao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Ogg1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ogg1 antibody (AB233214)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ogg1 antibody (AB233214)

Western blot - Anti-Ogg1 antibody (AB233214)

Western blot - Anti-Ogg1 antibody (AB233214)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Primary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise