Rabbit Polyclonal OGR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GPR68 conjugated to Keyhole Limpet Haemocyanin.
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Publications
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- International journal of molecular sciences 20:2019Comprehensive Assessment of GPR68 Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarkus Herzig et. al.PubMed 31652823
- FASEB journal : official publication of the Federa 32:1170-11832018GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShu Z Wiley et. al.PubMed 29092903
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.7
Preservative: 0.1% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human GPR68 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q15743
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 20 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
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Target data
Function
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity).
Alternative names
OGR1, GPR68, Ovarian cancer G-protein coupled receptor 1, OGR-1, G-protein coupled receptor 68, GPR12A, Sphingosylphosphorylcholine receptor
Recommended products
Rabbit Polyclonal OGR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GPR68 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.7
Preservative: 0.1% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human GPR68 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q15743
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
OGR1 also known as Ovarian Cancer G-Protein Coupled Receptor 1 is a proton-sensing G-protein coupled receptor. It has a molecular mass of approximately 41 kDa. This receptor mainly locates in tissues such as the brain heart kidney and lung. OGR1 functions by sensing extracellular changes in pH effectively detecting slight acidic conditions which then triggers intracellular signaling pathways relevant to its environment.
- Biological function summary
OGR1 modulates various cellular processes through its ability to act as a proton sensor. It participates in the regulation of immune responses bone homeostasis and vascular functions. Being part of the G-protein coupled receptor (GPCR) family it interacts with a variety of intracellular effectors mediating diverse physiological functions. In addition to its role in cellular pH response OGR1 is involved in tissue-specific processes showing its importance in maintaining cellular equilibrium.
- Pathways
OGR1 plays an essential role in proton-sensing pathways that activate G-protein signaling. It is notably involved in the acid-sensing pathway contributing to the regulation of immune and inflammatory responses. OGR1 interacts with related proteins such as Gαq and Gαi which are part of the G-protein complex that influences intracellular calcium levels and other second messenger systems therefore impacting cell signaling cascades.
- Associated diseases and disorders
OGR1 has a significant association with conditions like osteoporosis and cancer specifically ovarian cancer. This receptor's role in bone metabolism links it to diseases marked by bone density loss. Additionally OGR1's expression in various cancer types including ovarian cancer suggests its involvement in tumorigenesis and metastasis processes. The receptor’s connection to pathways involving proteins such as FAK and ERK highlights its relevance in cancer biology marking it as a potential target for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OGR1 antibody (ab61420)
ab61420, at 20μg/ml, staining human GPR68 in testis by immunohistochemistry. Formalin-fixed paraffin-embedded tissue.
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