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AB61420

Anti-OGR1 antibody

4

(1 Review)

|

(2 Publications)

Rabbit Polyclonal OGR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GPR68 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

OGR1, GPR68, G-protein coupled receptor 68, G-protein coupled receptor 12A, Ovarian cancer G-protein coupled receptor 1, GPR12A, OGR-1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OGR1 antibody (AB61420)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OGR1 antibody (AB61420)

ab61420, at 20μg/ml, staining human GPR68 in testis by immunohistochemistry. Formalin-fixed paraffin-embedded tissue.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human GPR68 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q15743

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.7 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OGR1 also known as Ovarian Cancer G-Protein Coupled Receptor 1 is a proton-sensing G-protein coupled receptor. It has a molecular mass of approximately 41 kDa. This receptor mainly locates in tissues such as the brain heart kidney and lung. OGR1 functions by sensing extracellular changes in pH effectively detecting slight acidic conditions which then triggers intracellular signaling pathways relevant to its environment.
Biological function summary

OGR1 modulates various cellular processes through its ability to act as a proton sensor. It participates in the regulation of immune responses bone homeostasis and vascular functions. Being part of the G-protein coupled receptor (GPCR) family it interacts with a variety of intracellular effectors mediating diverse physiological functions. In addition to its role in cellular pH response OGR1 is involved in tissue-specific processes showing its importance in maintaining cellular equilibrium.

Pathways

OGR1 plays an essential role in proton-sensing pathways that activate G-protein signaling. It is notably involved in the acid-sensing pathway contributing to the regulation of immune and inflammatory responses. OGR1 interacts with related proteins such as Gαq and Gαi which are part of the G-protein complex that influences intracellular calcium levels and other second messenger systems therefore impacting cell signaling cascades.

OGR1 has a significant association with conditions like osteoporosis and cancer specifically ovarian cancer. This receptor's role in bone metabolism links it to diseases marked by bone density loss. Additionally OGR1's expression in various cancer types including ovarian cancer suggests its involvement in tumorigenesis and metastasis processes. The receptor’s connection to pathways involving proteins such as FAK and ERK highlights its relevance in cancer biology marking it as a potential target for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed : 12955148, PubMed : 29677517, PubMed : 32865988, PubMed : 33478938, PubMed : 39753132, PubMed : 40215959, PubMed : 40215960). The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed : 12955148, PubMed : 39753132). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed : 29677517, PubMed : 39753132). GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed : 29677517, PubMed : 39753132). Acts as a key mechanosensor of fluid shear stress and membrane stretch (PubMed : 29677517, PubMed : 30471999). Expressed in endothelial cells of small-diameter resistance arteries, where it mediates flow-induced dilation in response to shear stress (PubMed : 29677517). May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone (By similarity). Acts as a regulator of calcium-sensing receptor CASR in a seesaw manner : GPR68-mediated signaling inhibits CASR signaling in response to protons, while CASR inhibits GPR68 in presence of extracellular calcium (By similarity).
See full target information GPR68
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 20: PubMed31652823

2019

Comprehensive Assessment of GPR68 Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody.

Applications

Unspecified application

Species

Unspecified reactive species

Markus Herzig,Pooja Dasgupta,Daniel Kaemmerer,Jörg Sänger,Katja Evert,Stefan Schulz,Amelie Lupp

FASEB journal : official publication of the Federa 32:1170-1183 PubMed29092903

2018

GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Shu Z Wiley,Krishna Sriram,Wenjing Liang,Sarah E Chang,Randall French,Thalia McCann,Jason Sicklick,Hiroshi Nishihara,Andrew M Lowy,Paul A Insel
View all publications
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Product promise

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