JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB191694

Anti-Olig1 antibody - N-terminal

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal OLIG1 antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OLIG1.

View Alternative Names

BHLHB6, BHLHE21, OLIG1, Oligodendrocyte transcription factor 1, Oligo1, Class B basic helix-loop-helix protein 6, Class E basic helix-loop-helix protein 21, bHLHb6, bHLHe21

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Olig1 antibody - N-terminal (AB191694)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Olig1 antibody - N-terminal (AB191694)

Immunohistochemical analysis of human brain tissue, labeling Olig1 using ab191694 at 20 μg/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Olig1 antibody - N-terminal (AB191694)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Olig1 antibody - N-terminal (AB191694)

Immunohistochemical analysis of paraffin-embedded Human brain tissue, labeling Olig1 using ab191694 at 5 μg/mL.

Western blot - Anti-Olig1 antibody - N-terminal (AB191694)
  • WB

Supplier Data

Western blot - Anti-Olig1 antibody - N-terminal (AB191694)

All lanes:

Western blot - Anti-Olig1 antibody - N-terminal (ab191694) at 1 µg/mL

All lanes:

A549 cell lysate at 15 µg

Predicted band size: 27 kDa

Observed band size: 29 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human OLIG1. The exact immunogen used to generate this antibody is proprietary information.

Q8TAK6

Specificity

ab191694 is predicted to not cross-react with other members of the OLIG family of proteins.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab191694 is affinity chromatography purified via peptide column.
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Olig1 also known as oligodendrocyte lineage transcription factor 1 is a protein involved in the development and function of oligodendrocytes cells that form the myelin sheath in the central nervous system. It weighs approximately 30 kDa and is expressed primarily in the brain and spinal cord. The protein plays a fundamental role in the maturation process of oligodendrocyte progenitor cells by regulating the transcription of genes necessary for myelination.
Biological function summary

Olig1 is important in the differentiation of progenitor cells into mature oligodendrocytes. It interacts with other proteins like Olig2 often forming heterodimer complexes that enhance transcriptional regulation. Olig1's regulatory actions influence cellular processes pivotal for maintaining neural integrity and function aiding in the production of myelin which is essential for fast and efficient nerve signal transmission in the central nervous system.

Pathways

Olig1 contributes significantly to the oligodendrocyte differentiation and development pathway as well as the myelination process. It works closely with Olig2 with both proteins being regulated within the Sonic Hedgehog signaling pathway. This pathway is vital for neural cell fate determination and contributes to the development of the nervous system ensuring proper function and communication within central nervous system.

Olig1 plays a role in multiple sclerosis and leukodystrophies where myelination is impaired. Abnormal regulation or expression of Olig1 can lead to demyelination a characteristic feature of these diseases. It is also associated with Olig2 which is similarly implicated in these neurological disorders. Understanding Olig1's involvement opens potential targets for therapeutic approaches in treating diseases affecting myelin and oligodendrocyte function.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).
See full target information OLIG1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:7022 PubMed40016272

2025

Hepatic lipid metabolism is altered in Ubiad1 mice of both sexes.

Applications

Unspecified application

Species

Unspecified reactive species

Ryoko Higa,Shirin Pourteymour,Pratibha S Kolan,Simon N Dankel,Johan Fernø,Gunnar Mellgren,Calvin Pan,Marcus M Seldin,Aldons J Lusis,Christian A Drevon,Knut T Dalen,Frode A Norheim
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB109127

Anti-c-Myb antibody [EPR718(2)]

RabMAb|Recombinant|KO Validated

Western blot - Anti-c-Myb antibody [EPR718(2)] (AB109127)

  • 0
  • 0
Primary Antibodies

AB76543

Anti-PU.1/Spi1 antibody [EPR3158Y]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PU.1/Spi1 antibody [EPR3158Y] (AB76543)

  • 5
  • 3
Primary Antibodies

AB6319

Anti-CNPase antibody [11-5B]

BOND RX™ Validated|KO Validated

Western blot - Anti-CNPase antibody [11-5B] (AB6319)

  • 5
  • 39
Primary Antibodies

AB46154

Anti-VEGFA antibody

Lab Essentials

Western blot - Anti-VEGFA antibody (AB46154)

  • 5
  • 29

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com