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AB183487

Anti-Olig2 (phospho S10 + S13 + S14) antibody

5

(2 Reviews)

|

(2 Publications)

Rabbit Polyclonal Olig2 phospho S10 + S13 + S14 antibody. Suitable for WB and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human OLIG2 phospho S13 + S14 conjugated to Keyhole Limpet Haemocyanin.
1 Images
Western blot - Anti-Olig2 (phospho S10 + S13 + S14) antibody (AB183487)
  • WB

Supplier Data

Western blot - Anti-Olig2 (phospho S10 + S13 + S14) antibody (AB183487)

All lanes:

Western blot - Anti-Olig2 (phospho S10 + S13 + S14) antibody (ab183487) at 1/1000 dilution

Lane 1:

Rat neonatal brain lysate

Lane 2:

Rat neonatal brain lysate with immunizing phosphopeptide

Predicted band size: 32 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human OLIG2 phospho S13 + S14 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q13516

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab183487 is prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
Storage buffer
pH: 7.5 Constituents: 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.24% HEPES, 0.01% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Olig2 also known as Oligo2 or OLIG2 is a protein with a molecular mass of around 32 kDa. It belongs to the basic helix-loop-helix (bHLH) family of transcription factors which play roles in neurodevelopment. Olig2 is expressed mainly in the central nervous system particularly in oligodendrocyte progenitor cells and motor neuron progenitors. As an important marker Olig2 staining is often used in studies involving these cell types to understand differentiation processes.
Biological function summary

Olig2 regulates gene expression important for the proper development of the central nervous system. It functions both independently and as a part of transcriptional complexes to influence the fate of neural progenitors. In particular its presence decides whether these progenitors will differentiate into neurons astrocytes or oligodendrocytes. Among the proteins it interacts with are factors that modulate neurogenesis and myelination highlighting its importance in maintaining normal brain homeostasis.

Pathways

Olig2 plays an important role in the oligodendrocyte differentiation and motor neuron generation pathways. It works closely with proteins such as SOX10 and NKX2.2 to regulate oligodendrocyte maturation. In the motor neuron pathway Olig2 interacts with proteins like NKX6.1 and LHX3 coordinating the development of motor neurons. These pathways demonstrate Olig2's function as a critical transcription factor influencing neural development and plasticity.

Abnormalities in Olig2 expression or function relate to conditions such as gliomas and Multiple Sclerosis (MS). Elevated levels of Olig2 are often seen in gliomas where it might cooperate with proteins like IDH1 to drive tumor growth. In MS the impairment of oligodendrocyte function can link back to disruptions in normal Olig2 activity or expression. These associations make Olig2 a significant target for potential therapeutic interventions in neurological conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Olig2 phospho S10 + S13 + S14
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell death and differentiation 27:3146-3161 PubMed32483381

2020

Olig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting.

Applications

Unspecified application

Species

Unspecified reactive species

Huiqing Liu,Weiji Weng,Rongjun Guo,Jie Zhou,Jun Xue,Shan Zhong,Jinke Cheng,Michael X Zhu,Si-Jian Pan,Yong Li

Oncotarget 8:22370-22384 PubMed26517684

2015

Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma.

Applications

WB

Species

Human

Igor F Tsigelny,Rajesh Mukthavaram,Valentina L Kouznetsova,Ying Chao,Ivan Babic,Elmar Nurmemmedov,Sandra Pastorino,Pengfei Jiang,David Calligaris,Nathalie Agar,Miriam Scadeng,Sandeep C Pingle,Wolfgang Wrasidlo,Milan T Makale,Santosh Kesari
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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