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Rabbit Polyclonal Oligodendrocyte myelin glycoprotein antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Oligodendrocyte-myelin glycoprotein aa 50-400.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (AB101567), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

Preservative: 0.02% Sodium azide

Form

Lyophilized

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human Oligodendrocyte-myelin glycoprotein aa 50-400. The exact immunogen used to generate this antibody is proprietary information. Database link P23515

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Mouse
Predicted
Rat
Predicted

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/500.00000

Notes

-

Predicted
Predicted

Species

Mouse, Rat

Dilution info

-

Notes

-

Associated Products

Select an associated product type

2 products for Alternative Product

Target data

Function

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Alternative names

Recommended products

Rabbit Polyclonal Oligodendrocyte myelin glycoprotein antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Oligodendrocyte-myelin glycoprotein aa 50-400.

Key facts

Isotype

IgG

Form

Lyophilized

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human Oligodendrocyte-myelin glycoprotein aa 50-400. The exact immunogen used to generate this antibody is proprietary information. Database link P23515
Purification technique

Affinity purification Protein A

Reconstitution

Reconstitute in 200 µL of water

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Oligodendrocyte myelin glycoprotein (OMGP) also known as oligodendrocyte myelin marker has a molecular weight of approximately 50 kDa. It is a glycoprotein primarily found in the myelin of the central nervous system (CNS) notably in the white matter. OMGP appears as an element on the surface of oligodendrocytes and contributes significantly to the stability and function of the myelin sheath.

Biological function summary

OMGP plays an essential role in the CNS where it interacts with other structural components to maintain myelin integrity. OMGP is not a component of a larger complex but works closely with other myelin proteins such as myelin basic protein. It also inhibits neurite outgrowth helping regulate neural plasticity and potentially preventing improper nerve regeneration in mature central nervous systems.

Pathways

Research recognized OMGP as a contributor in the Nogo receptor (NgR) signaling pathway influencing the inhibition of axonal growth. Within this pathway OMGP associates with other proteins like Nogo-A and the receptor NgR1 regulating neuronal growth by binding to these proteins and suppressing neurite outgrowth. This interaction is important in maintaining the structural arrangement of the CNS and modulating its repair mechanisms.

Associated diseases and disorders

OMGP has connections with multiple sclerosis (MS) and some neurodegenerative diseases. In MS changes in OMGP expression correlate with demyelination and faulty nerve function. Moreover OMGP interrelates with Nogo-A another protein present in damaged myelin which may influence disease progression by hindering nerve repair. ALS (Amyotrophic Lateral Sclerosis) research also considers OMGP's role in neurodegeneration suggesting a broader impact on CNS pathologies.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (ab101567), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (ab101567)

    ab101567, at a 1/100 dilution, showing membrane staining of Oligodendrocyte myelin glycoprotein in a formalin fixed, paraffin embedded section of Human fetal brain by Immunohistochemistry.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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