JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB224254

Anti-Oligodendrocyte myelin glycoprotein antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Oligodendrocyte myelin glycoprotein antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human OMG aa 1-200.

View Alternative Names

OMGP, OMG, Oligodendrocyte-myelin glycoprotein

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)

Paraffin-embedded human caudate nucleus stained for OMG using ab224254 at 1/1000 dilution in immunohistochemical analysis. Shows moderate to strong positivity in neuronal processes.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)

Paraffin-embedded human liver stained for OMG using ab224254 at 1/1000 dilution in immunohistochemical analysis. Shows no positivity in in hepatocytes as expected.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)

Paraffin-embedded human cerebral cortex stained for OMG using ab224254 at 1/1000 dilution in immunohistochemical analysis. Shows moderate positivity in neurophil, as well as glial cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)

Paraffin-embedded human kidney stained for OMG using ab224254 at 1/1000 dilution in immunohistochemical analysis. Shows no positivity in cells in tubules as expected.

Western blot - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)
  • WB

Supplier Data

Western blot - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)

All lanes:

Western blot - Anti-Oligodendrocyte myelin glycoprotein antibody (ab224254) at 1/100 dilution

Lane 1:

RT4 (human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG sp (human brain glioma cell line) cell lysate

Predicted band size: 50 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human OMG aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P23515

style
left-column

Complementary Products

Assay Kits

AB313914

Human Oligodendrocyte myelin glycoprotein ELISA Kit

Sandwich ELISA - Human Oligodendrocyte myelin glycoprotein ELISA Kit (AB313914)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB46803

Anti-MAG/GMA antibody [EP971Y]

RabMAb|Recombinant

Western blot - Anti-MAG/GMA antibody [EP971Y] (AB46803)

  • 1
  • 3
Primary Antibodies

AB7349

Anti-Myelin Basic Protein antibody [12] - Oligodendrocyte Marker

BOND RX™ Validated|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myelin Basic Protein antibody [12] - Oligodendrocyte Marker (AB7349)

  • 4
  • 23
Primary Antibodies

AB254363

Anti-Myelin PLP antibody [EPR23504-106]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myelin PLP antibody [EPR23504-106] (AB254363)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Oligodendrocyte myelin glycoprotein (OMGP) also known as oligodendrocyte myelin marker has a molecular weight of approximately 50 kDa. It is a glycoprotein primarily found in the myelin of the central nervous system (CNS) notably in the white matter. OMGP appears as an element on the surface of oligodendrocytes and contributes significantly to the stability and function of the myelin sheath.
Biological function summary

OMGP plays an essential role in the CNS where it interacts with other structural components to maintain myelin integrity. OMGP is not a component of a larger complex but works closely with other myelin proteins such as myelin basic protein. It also inhibits neurite outgrowth helping regulate neural plasticity and potentially preventing improper nerve regeneration in mature central nervous systems.

Pathways

Research recognized OMGP as a contributor in the Nogo receptor (NgR) signaling pathway influencing the inhibition of axonal growth. Within this pathway OMGP associates with other proteins like Nogo-A and the receptor NgR1 regulating neuronal growth by binding to these proteins and suppressing neurite outgrowth. This interaction is important in maintaining the structural arrangement of the CNS and modulating its repair mechanisms.

OMGP has connections with multiple sclerosis (MS) and some neurodegenerative diseases. In MS changes in OMGP expression correlate with demyelination and faulty nerve function. Moreover OMGP interrelates with Nogo-A another protein present in damaged myelin which may influence disease progression by hindering nerve repair. ALS (Amyotrophic Lateral Sclerosis) research also considers OMGP's role in neurodegeneration suggesting a broader impact on CNS pathologies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.
See full target information OMG
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:6446 PubMed37833281

2023

Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication.

Applications

Unspecified application

Species

Unspecified reactive species

Chaitali Chakraborty,Itzel Nissen,Craig A Vincent,Anna-Carin Hägglund,Andreas Hörnblad,Silvia Remeseiro
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com