AB175236

Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker

RabMAb
Recombinant
Lab Essentials
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(3 Publications)

Rabbit Recombinant Monoclonal Oligodendrocyte Specific Protein antibody. Oligodendrocyte marker. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

OSP, OTM, CLDN11, Claudin-11, Oligodendrocyte-specific protein

2 Images

Flow Cytometry - Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker (AB175236)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker (AB175236)

Flow Cytometrical analysis of U87-MG cells labeling Oligodendrocyte Specific Protein with ab175236 antibody at a dilution of 1/100 (red) or a rabbit IgG (negative) (green).

Supplier Data

Western blot - Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker (AB175236)

All lanes:

Western blot - Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker (ab175236) at 1/1000 dilution

Lane 1:

Human oligodendroglioma lysate at 10 µg

Lane 2:

U87-MG lysate at 10 µg

Lane 3:

SH-SY5Y lysate at 10 µg

Lane 4:

Fetal brain lysate at 10 µg

Lane 5:

Human testis lysate at 10 µg

Predicted band size: 22 kDa

false

Carrier free

Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12726

Isotype

IgG

Carrier free

Reacts with

Human

Applications

Flow Cyt, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Oligodendrocyte Specific Protein also known as O4 or O4 protein is an important marker for oligodendrocytes. This protein has a mass of approximately 24 kDa. Predominantly it is expressed in the central nervous system (CNS) specifically in oligodendrocyte precursor cells (OPCs) and mature oligodendrocytes. Its presence marks the differentiation stage of oligodendrocytes serving as an indicator of their development and maturation.

Biological function summary

The oligodendrocyte marker O4 plays a significant role in the myelination process supporting the formation of the myelin sheath around neurons. O4 does not act as part of a complex but is essential in the identification of oligodendrocyte lineage cells. During development it signals the transition of OPCs into mature myelinating oligodendrocytes which are necessary for effective neuronal signal transmission in the CNS.

Pathways

Oligodendrocyte marker O4 influences critical processes in the nervous system namely the myelination pathway. It interacts with various proteins including myelin basic protein (MBP) involved in the formation and maintenance of the myelin sheath. The presence of O4 marks the progression along the oligodendrocyte lineage and fits within the larger framework of CNS development and repair indicating a healthy state of neuronal insulation.

Disruptions involving the oligodendrocyte marker O4 can relate to multiple sclerosis (MS) and leukodystrophies. These conditions arise from demyelination or abnormal myelination respectively. O4 in association with other proteins like MBP and proteolipid protein (PLP) can serve as a biomarker for disease activity and progression. Its expression levels may assist in the research and diagnosis of demyelinating diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

See full target information CLDN11

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Andrologia 54:e14342 PubMed34872158

2021

Dietary high-fructose reduces barrier proteins and activates mitogenic signalling in the testis of a rat model: Regulatory effects of kefir supplementation.

Applications

Unspecified application

Species

Unspecified reactive species

Fatma Akar,Onur Gokhan Yildirim,Gozde Yucel Tenekeci,Arda Selin Tunc,Murside Ayse Demirel,Gokhan Sadi

OncoTargets and therapy 12:5751-5765 PubMed31410021

2019

Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Bili Wang,Can Shen,Yang Li,Ting Zhang,Hui Huang,Jun Ren,Zhengjun Hu,Jian Xu,Bin Xu

Cell communication and signaling : CCS 17:57 PubMed31142324

2019

Androgen promotes differentiation of PLZF spermatogonia pool via indirect regulatory pattern.

Applications

Unspecified application

Species

Unspecified reactive species

Jingjing Wang,Jinmei Li,Wei Xu,Qin Xia,Yunzhao Gu,Weixiang Song,Xiaoyu Zhang,Yang Yang,Wei Wang,Hua Li,Kang Zou

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker

Flow Cytometry - Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker (AB175236)

Western blot - Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker (AB175236)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise