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AB154249

Anti-OMD antibody

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(2 Publications)

Rabbit Polyclonal OMD antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OMD aa 150 to C-terminus.

View Alternative Names

SLRR2C, UNQ190/PRO216, OMD, Osteomodulin, Keratan sulfate proteoglycan osteomodulin, Osteoadherin, KSPG osteomodulin, OSAD

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OMD antibody (AB154249)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OMD antibody (AB154249)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling OMD with ab154249 at 1/500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OMD antibody (AB154249)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OMD antibody (AB154249)

Immunohistochemical analysis of paraffin-embedded mouse muscle tissue labeling OMD with ab154249 at 1/500 dilution.

Western blot - Anti-OMD antibody (AB154249)
  • WB

Unknown

Western blot - Anti-OMD antibody (AB154249)

10% SDS PAGE

All lanes:

Western blot - Anti-OMD antibody (ab154249) at 1/500 dilution

Lane 1:

A549 whole cell lysate at 30 µg

Lane 2:

MCF7 whole cell lysate at 30 µg

Predicted band size: 49 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human OMD aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q99983

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Osteomodulin (OMD) also referred to as osteoadherin is a small leucine-rich proteoglycan with a molecular weight of approximately 48 kDa. This protein plays a significant role in bone biology and is primarily expressed in mineralized tissues such as osteoblasts and dentin. OMD contains multiple leucine-rich repeats that facilitate its interaction with collagen fibrils suggesting a role in the regulation of collagen assembly and matrix organization.
Biological function summary

The functions of osteomodulin contribute to maintaining bone structure and integrity. It binds to type I collagen and assists in organizing the extracellular matrix in bone tissue. OMD is not part of a larger protein complex but acts individually to stabilize the mineralized matrix. Its presence is essential for proper bone mineralization and it participates in cell signaling that governs osteogenic differentiation.

Pathways

Osteomodulin has involvement in bone development and remodeling processes. It plays a part in the TGF-beta signaling pathway which is important for bone matrix production and maintenance. OMD interacts with other matrix-related proteins including decorin and biglycan through these pathways supporting structural integrity and influencing cellular responses.

Osteomodulin's dysfunction connects to bone-related pathologies like osteoarthritis and osteoporosis. Abnormal expression of OMD can disrupt collagen regulation contributing to these conditions. It may also influence interactions with other proteins involved in these diseases such as matrix metalloproteinases further affecting tissue degradation and remodeling in diseased states.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin.
See full target information OMD

Additional targets

Omd
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 28:515 PubMed39247492

2024

Analysis of metastasis‑related risk factors and clinical relevance in adult soft‑tissue sarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shuai Han,Xin Song,Jialiang Liu,Jingfen Zhou,Zhipeng Wu,Haihan Song,Jun Tao,Jian Wang

Arthritis & rheumatology (Hoboken, N.J.) 67:435-41 PubMed25371314

2014

Distinct dysregulation of the small leucine-rich repeat protein family in osteoarthritic acetabular labrum compared to articular cartilage.

Applications

Unspecified application

Species

Unspecified reactive species

Nele Juchtmans,Aad A M Dhollander,Julie Coudenys,Emmanuel A Audenaert,Christophe Pattyn,Stijn Lambrecht,Dirk Elewaut
View all publications
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