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AB230205

Anti-OPA3 antibody

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(2 Publications)

Rabbit Polyclonal OPA3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OPA3 aa 1 to C-terminus.

View Alternative Names

Optic atrophy 3 protein, OPA3

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-OPA3 antibody (AB230205)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-OPA3 antibody (AB230205)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for OPA3 (green) using ab230205 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® congugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OPA3 antibody (AB230205)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OPA3 antibody (AB230205)

Paraffin-embedded human gastric cancer tissue stained for OPA3 using ab230205 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OPA3 antibody (AB230205)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OPA3 antibody (AB230205)

Paraffin-embedded human kidney tissue stained for OPA3 using ab230205 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human OPA3 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9H6K4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OPA3 also known as Optic Atrophy 3 or Optic atrophy protein 3 is a protein with a mass of approximately 36 kDa. This protein is mainly present in the mitochondria which are responsible for energy production in cells. It plays an essential mechanical role in maintaining mitochondrial integrity. The gene encoding OPA3 expresses in various tissues with notable levels in the brain skeletal muscle and to some extent in other organs like the liver and kidney.
Biological function summary

The role of OPA3 is significant due to its involvement in the regulation of mitochondrial dynamics. It helps balance mitochondrial fusion and fission processes that ensure proper mitochondrial function and energy production. OPA3 participates in a complex that includes several other mitochondrial proteins necessary for preserving mitochondrial structure and function. This complex contributes to the regulation of metabolic pathways that are important for normal cellular function.

Pathways

The involvement of OPA3 in mitochondrial dynamics links it closely to the mitochondrial fission and fusion pathways. These pathways are critical for mitochondrial quality control which affects cellular energy homeostasis and apoptosis. Proteins like MFN1 and DRP1 interact with or relate to OPA3 as they play roles in the same pathways contributing to maintaining mitochondrial health and preventing cellular stress.

The impairment of OPA3 function associates with conditions such as autosomal dominant optic atrophy and Costeff syndrome. Optic atrophy linked with OPA3 leads to degeneration in optic nerve fibers and consequent vision loss. Costeff syndrome a disorder that affects multiple body systems also involves defects in OPA3. Such conditions highlight connections with proteins like MFN2 known for involvement in Charcot-Marie-Tooth disease underlining the importance of mitochondrial health to prevent neural and optic disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play some role in mitochondrial processes.
See full target information OPA3
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncology reports 46: PubMed34278506

2021

miR‑367‑3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Du,Dong Li,Jianhao Xie,Ping Tang

Cancers 12: PubMed31881642

2019

Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Meng,Christophe Glorieux,Yanyu Zhang,Liyun Liang,Peiting Zeng,Wenhua Lu,Peng Huang
View all publications
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