JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB69163

Anti-OPA3 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Polyclonal OPA3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human OPA3.

View Alternative Names

Optic atrophy 3 protein, OPA3

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human OPA3.

Q9H6K4

style
left-column

Alternative Products

Primary Antibodies

AB230205

Anti-OPA3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-OPA3 antibody (AB230205)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB42364

Anti-OPA1 antibody

Immunoprecipitation - Anti-OPA1 antibody (AB42364)

  • 3
  • 7
Proteins & Peptides

AB164221

Recombinant Human OPA3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human OPA3 protein (GST tag N-Terminus) (AB164221)

  • 0
  • 0
Primary Antibodies

AB156865

Anti-TTC11/FIS1 antibody [EPR8412]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TTC11/FIS1 antibody [EPR8412] (AB156865)

  • 5
  • 3
Primary Antibodies

AB129075

Anti-MFF antibody [EPR7360]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-MFF antibody [EPR7360] (AB129075)

  • 0
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: 91% Water, 8% Sodium chloride, 0.6% Disodium hydrogenorthophosphate, 0.2% Potassium chloride, 0.2% Potassium phosphate monobasic
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

OPA3 also known as Optic Atrophy 3 or Optic atrophy protein 3 is a protein with a mass of approximately 36 kDa. This protein is mainly present in the mitochondria which are responsible for energy production in cells. It plays an essential mechanical role in maintaining mitochondrial integrity. The gene encoding OPA3 expresses in various tissues with notable levels in the brain skeletal muscle and to some extent in other organs like the liver and kidney.
Biological function summary

The role of OPA3 is significant due to its involvement in the regulation of mitochondrial dynamics. It helps balance mitochondrial fusion and fission processes that ensure proper mitochondrial function and energy production. OPA3 participates in a complex that includes several other mitochondrial proteins necessary for preserving mitochondrial structure and function. This complex contributes to the regulation of metabolic pathways that are important for normal cellular function.

Pathways

The involvement of OPA3 in mitochondrial dynamics links it closely to the mitochondrial fission and fusion pathways. These pathways are critical for mitochondrial quality control which affects cellular energy homeostasis and apoptosis. Proteins like MFN1 and DRP1 interact with or relate to OPA3 as they play roles in the same pathways contributing to maintaining mitochondrial health and preventing cellular stress.

The impairment of OPA3 function associates with conditions such as autosomal dominant optic atrophy and Costeff syndrome. Optic atrophy linked with OPA3 leads to degeneration in optic nerve fibers and consequent vision loss. Costeff syndrome a disorder that affects multiple body systems also involves defects in OPA3. Such conditions highlight connections with proteins like MFN2 known for involvement in Charcot-Marie-Tooth disease underlining the importance of mitochondrial health to prevent neural and optic disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May play some role in mitochondrial processes.
See full target information OPA3
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 45:429-440 PubMed31894293

2020

Inhibition of miR‑155‑5p attenuates the valvular damage induced by rheumatic heart disease.

Applications

Unspecified application

Species

Unspecified reactive species

Ang Chen,Jianlin Wen,Chuanghong Lu,Beiyou Lin,Shenglin Xian,Feng Huang,Yunjiao Wu,Zhiyu Zeng
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com