Rabbit Polyclonal OPN3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OPN3.
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- Scientific reports 13:199542023Effects of green light-emitting diode irradiation on hepatic differentiation of hepatocyte-like cells generated from human adipose-derived mesenchymal cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYuhei Waki,Yu Saito,Shuhai Chen,Tetsuya Ikemoto,Takayuki Noma,Hiroki Teraoku,Shinichiro Yamada,Yuji Morine,Mitsuo ShimadaPubMed 37968291
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human OPN3. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H1Y3
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Dog | Predicted |
| Monkey | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 2.00000-36.00000 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Dog, Monkey | Dilution info - | Notes - |
Associated Products
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Target data
Function
G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed:28842328, PubMed:31097585, PubMed:31380578). Binds both 11-cis retinal and all-trans retinal (PubMed:31097585). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (PubMed:28842328, PubMed:31097585). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (PubMed:31730232). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (PubMed:31730232). Required for TYR and DCT blue light-induced complex formation in melanocytes (PubMed:28842328). Involved in keratinocyte differentiation in response to blue-light (PubMed:30168605). Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (PubMed:31380578). Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (By similarity). May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways (By similarity).
Alternative names
ECPN, OPN3, Opsin-3, Encephalopsin, Panopsin
Recommended products
Rabbit Polyclonal OPN3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human OPN3.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human OPN3. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H1Y3
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
OPN3 also known as Opsin 3 or encephalopsin is a protein that functions mechanically as a part of the G protein-coupled receptor (GPCR) family which are involved in signal transduction. This protein has an approximate mass of 39 kDa. Research shows OPN3 expression in various human tissues such as the brain and liver indicating its diverse roles throughout the body.
- Biological function summary
OPN3 plays a role in several physiological processes beyond its classical function in photoreception. While not a part of a larger complex it modulates different signaling pathways influencing cellular responses to environmental changes. Such actions make OPN3 a point of interest for understanding its function in non-visual opsin behaviors.
- Pathways
OPN3 links to important biological processes like circadian rhythm regulation and cellular responses to light. It interacts with signaling proteins like G-proteins which help mediate its effects in these pathways. This connection suggests its involvement in mechanisms similar to other light-sensitive proteins.
- Associated diseases and disorders
OPN3 shows a relation to conditions such as seasonal affective disorder and other mood-related disorders. Research points to OPN3's impact on circadian-related symptoms where proteins similar to OPN3 such as melanopsin also play roles. This suggests potential therapeutic implications for OPN3 in managing these conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OPN3 antibody (ab140901)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, neurons and glia labelling OPN3 with ab140901 at 36 μg/ml (after heat-induced antigen retrieval).
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