Rabbit Polyclonal Orexin antibody. Suitable for ELISA, WB and reacts with Mouse samples. Cited in 1 publication.
pH: 7.4
Preservative: Proprietary preservative
Constituents: PBS, 0.1% BSA
| ELISA | WB | |
|---|---|---|
| Mouse | Expected | Expected |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A. Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity). Orexin-B. Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity).
Ox, Ppox, Hcrt, Hypocretin neuropeptide precursor, Hypocretin, Orexin precursor, Prepro-orexin, Preprohypocretin
Rabbit Polyclonal Orexin antibody. Suitable for ELISA, WB and reacts with Mouse samples. Cited in 1 publication.
pH: 7.4
Preservative: Proprietary preservative
Constituents: PBS, 0.1% BSA
Purified by antigen affinity chromatography.
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
The orexin prepro also known as prepro-orexin is a precursor molecule with a mass of approximately 16-18 kDa. It undergoes proteolytic cleavage to form orexin-A and orexin-B neuropeptides. These peptides play an essential role in maintaining wakefulness and energy homeostasis. The orexin prepro is mainly expressed in the hypothalamus particularly in the lateral hypothalamic area where it acts on orexin receptors distributed widely across the brain.
The orexin neuropeptides derived from the orexin prepro are important for regulating sleep-wake cycles appetite and arousal. While not part of a larger complex orexins are significant modulators of other neurotransmitter systems including noradrenaline dopamine and serotonin. These interactions influence many physiological functions further demonstrating the importance of orexins in maintaining overall body balance.
Orexin prepro-derived neuropeptides engage in the sleep-wake regulation and energy homeostasis pathways. They interact directly with orexin receptors such as OX1R and OX2R to affect these pathways. The insulin signaling pathway also involves orexin peptides linking them with metabolic regulation. Other proteins such as leptin and ghrelin interact with orexins indicating the overlap of neuronal and metabolic pathways in which orexins play.
Disruptions in orexin signaling have strong associations with narcolepsy and obesity. Narcolepsy characterized by fragmented sleep-wake cycles shows a loss of orexin-producing neurons. Obesity relates to orexin through its involvement in appetite regulation and energy balance with dysregulation leading to weight gain. Orexin peptides and their receptors are potential therapeutic targets for these conditions creating connections with other proteins like melanin-concentrating hormone involved in energy homeostasis and sleep regulation.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com