Endosome and caveolae markers

Track the movement of proteins through the endocytic pathway with validated endosome marker antibodies for early, late, and recycling endosomes, as well as caveolae. Part of a catalog of 60k+ primary antibodies with 600k+ citations, these high-performance antibodies, including Rab5, Rab7, and Caveolin-1, provide the specific target detection required to map complex membrane dynamics and intracellular trafficking with total precision.

Endosome

What is an endosome?

Endosomes are dynamic, membrane-bound organelles that mediate intracellular trafficking, sorting, and recycling of cargo between the plasma membrane, Golgi apparatus, and lysosomes. From an organelle marker perspective, endosomes are characterized by distinct proteins that define their maturation and function.

Endosome stage

Marker protein

Function

Localization

Early endosome

EEA1 (Early Endosome Antigen 1)

Mediates tethering and fusion after endocytosis

Early endosomal membranes

Early endosome

Rab5

Regulates vesicle docking and fusion

Early endosomes

Late endosome

RAB7

Controls maturation and fusion with lysosomes

Late endosomes

Late endosome

CD63

Associated with multivesicular bodies and cargo sorting

Late endosomes/MVBs

Early endosomes are marked by EEA1 (Early Endosome Antigen 1), which plays a key role in tethering and fusion events shortly after endocytosis. As endosomes mature, they acquire RAB7, a small GTPase that marks late endosomes and facilitates their fusion with lysosomes for cargo degradation. Another important marker is CD63, commonly associated with multivesicular bodies and late endosomal compartments.

What are endosome markers used to study?

Endosome markers are essential for studying vesicular trafficking, receptor recycling, and endosome maturation, providing insight into how cells maintain homeostasis and respond to environmental signals.

High-quality endosome marker antibodies

Early endosome markers

abcam:product-category/primary-antibodies

ab109110

Anti-EEA1 antibody [EPR4245] - Early Endosome Marker

Validated for WB, ICC/IF
KO validated for confirmed specificity
Over 10 publications

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abcam:product-category/primary-antibodies

ab218624

Anti-Rab5 antibody [EPR21801] - Early Endosome Marker

Validated for western blot, flow cytometry (intra), flow cytometry, IP, IHC-P, ICC/IF
KO validated for confirmed specificity
Over 10 publications

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Late endosome markers

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ab137029

Anti-RAB7 antibody [EPR7589] - Late Endosome Marker

Validated for western blot, flow cytometry (intra), flow cytometry, IHC-P, ICC/IF
KO validated for confirmed specificity
Over 100 publications

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abcam:product-category/primary-antibodies

ab134045

Anti-CD63 antibody [EPR5702] - Late Endosome Marker

Validated for western blot, IHC-P
KO validated for confirmed specificity
Over 380 publications

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Caveolae

What are caveolae?

Caveolae are small, flask-shaped invaginations of the plasma membrane found in many vertebrate cells, especially in endothelial cells, adipocytes, and muscle cells. Rich in cholesterol, sphingolipids, and proteins, caveolae are a specialized type of lipid raft involved in endocytosis and signal transduction.

Marker protein

Function

Typical use

Caveolin-1

Structural component of caveolae; regulates signaling

General caveolae identification

Caveolin-2

Supports caveolae formation and stability

Membrane trafficking studies

Caveolin-3

Muscle-specific caveolae protein

Muscle cell biology research

What are caveolae markers used to study?

Caveolae markers, such as caveolin-1, caveolin-2, and caveolin-3 proteins, are used to study the formation, structure, and function of caveolae. These markers help researchers investigate cell signaling pathways, membrane trafficking, and the role of caveolae in diseases like cancer, cardiovascular disorders, and viral infections