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AB176122

Anti-ORMDL1 antibody

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(1 Publication)

Rabbit Polyclonal ORMDL1 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ORMDL1.

View Alternative Names

HSPC202, ORMDL1, ORM1-like protein 1, Adoplin-1

1 Images
Western blot - Anti-ORMDL1 antibody (AB176122)
  • WB

Supplier Data

Western blot - Anti-ORMDL1 antibody (AB176122)

Lane 1:

Western blot - Anti-ORMDL1 antibody (ab176122) at 1 µg/mL

Lane 2:

Western blot - Anti-ORMDL1 antibody (ab176122) at 2 µg/mL

All lanes:

SK-N-SH cell lysate at 15 µg

Predicted band size: 17 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ORMDL1. The exact immunogen used to generate this antibody is proprietary information.

Q9P0S3

Specificity

ab176122 may cross-react with other ORMDL protein family members.

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ORMDL1 protein also known as ORM1-like protein 1 is a member of the ORMDL family playing significant roles in cellular processes. With a mass of approximately 18 kDa ORMDL1 is a transmembrane protein localized in the endoplasmic reticulum. Expression of ORMDL1 occurs across various tissues indicating its broad functional significance in different physiological contexts.
Biological function summary

The main function of ORMDL1 involves regulation of sphingolipid biosynthesis. It forms a complex with serine palmitoyltransferase the enzyme responsible for the first step in sphingolipid synthesis. Through this interaction ORMDL1 modulates the synthesis rate of ceramides and other sphingolipids thereby influencing cell membrane structure and cellular signaling pathways. This regulatory mechanism is important for maintaining cellular homeostasis.

Pathways

The sphingolipid biosynthesis pathway involves interactions with ORMDL1 impacting cellular stress responses and apoptosis. Another relevant pathway includes the endoplasmic reticulum stress response where ORMDL1 interacts with proteins like ATF6. These interactions suggest the role of ORMDL1 in modulating responses to cellular stress and promoting survival by maintaining lipid equilibrium.

ORMDL1 is linked to conditions like asthma and type 2 diabetes. In asthma altered sphingolipid metabolism has been associated with airway inflammation where ORMDL1 might interact with related proteins like SPTLC1 affecting the inflammatory response. In type 2 diabetes the dysregulation of lipid metabolism involving ORMDL1 could play part in insulin resistance highlighting the importance of ORMDL1 in disease pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed : 20182505). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity).
See full target information ORMDL1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 15:2627-2633 PubMed29456666

2018

MicroRNA-125b-1-3p mediates intervertebral disc degeneration in rats by targeting teashirt zinc finger homeobox 3.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaotong Meng,Yue Zhu,Lin Tao,Sichao Zhao,Shui Qiu
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Product promise

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